HCSGD entry for XRCC4

1. General information

Official gene symbolXRCC4
Entrez ID7518
Gene full nameX-ray repair complementing defective repair in Chinese hamster cells 4
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000793Condensed chromosomeIDAcellular_component
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002328Pro-B cell differentiationIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolIDAcellular_component
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIDAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006302Double-strand break repairIDA TASbiological_process
GO:0006303Double-strand break repair via nonhomologous end joiningIDA IMP NAS TASbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0010165Response to X-rayIDAbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0016032Viral processTASbiological_process
GO:0016874Ligase activityIDAmolecular_function
GO:0032807DNA ligase IV complexIDAcellular_component
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0033152Immunoglobulin V(D)J recombinationIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045190Isotype switchingIEAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIEAbiological_process
GO:0050769Positive regulation of neurogenesisIEAbiological_process
GO:0051103DNA ligation involved in DNA repairIDAbiological_process
GO:0051351Positive regulation of ligase activityIDAbiological_process
GO:0070419Nonhomologous end joining complexIDAcellular_component
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0075713Establishment of integrated proviral latencyTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95322627560.00659110600.99999024730.1636646226

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2746729096
GSE13712_SHEARDown-0.0213983430
GSE13712_STATICDown-0.2245973993
GSE19018Up0.0333101518
GSE19899_A1Down-0.4540266340
GSE19899_A2Down-1.1923451886
PubMed_21979375_A1Down-1.3668833315
PubMed_21979375_A2Down-2.0420524415
GSE35957Up0.0098330766
GSE36640Up0.2242645972
GSE54402Down-0.5269781035
GSE9593Down-0.5488663441
GSE43922Down-0.8266341985
GSE24585Down-0.3585810738
GSE37065Up0.2505742145
GSE28863_A1Down-0.0224936082
GSE28863_A2Up0.3963611523
GSE28863_A3Down-0.4798974376
GSE28863_A4Up0.0503569819
GSE48662Down-0.5140846639

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

S-(Dimethylarsenic)CysteineDB03963 EXPT00832

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26224580Statins also impaired the expression of DNA repair genes, including XRCC4, XRCC6, and Apex1
25678531Genome-wide gene expression analysis revealed age-related impairment of mitosis, telomere and chromosome maintenance and induction of genes associated with DNA repair and non-homologous end-joining, most notably XRCC4 and ligase 4
17347130Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other that is independent of these factors
17347130Using a cell-free NHEJ assay, we have investigated the ability of three Chinese hamster ovary (CHO) mutants deficient in Ku80 (xrs6), DNA-PKcs (XR-C1) and XRCC4 (XR-1) in comparison with CHO-K1 wild-type cells to rejoin non-compatible DSB ends
16757976In addition, p53S18/23A, but not p53S18A, could completely rescue embryonic lethality of Xrcc4(-/-) mice that is caused by massive p53-dependent neuronal apoptosis
16757976Interestingly, Xrcc4(-/-)p53S18/23A mice fail to develop tumors like the pro-B cell lymphomas uniformly developed in Xrcc4(-/-) p53(-/-) animals, but exhibit developmental defects typical of accelerated ageing
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