HCSGD entry for CAD

1. General information

Official gene symbolCAD
Entrez ID790
Gene full namecarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004070Aspartate carbamoyltransferase activityIEA ISS TASmolecular_function
GO:0004088Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activityISS TASmolecular_function
GO:0004151Dihydroorotase activityISS TASmolecular_function
GO:0004672Protein kinase activityISSmolecular_function
GO:0005524ATP bindingIEA ISSmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006206Pyrimidine nucleobase metabolic processTASbiological_process
GO:0006207'de novo' pyrimidine nucleobase biosynthetic processIEA ISSbiological_process
GO:0006228UTP biosynthetic processIEAbiological_process
GO:0006520Cellular amino acid metabolic processIEAbiological_process
GO:0006541Glutamine metabolic processISSbiological_process
GO:0006543Glutamine catabolic processIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0014075Response to amineIEAbiological_process
GO:0016363Nuclear matrixIDAcellular_component
GO:0016597Amino acid bindingIEAmolecular_function
GO:0016743Carboxyl- or carbamoyltransferase activityIEAmolecular_function
GO:0016810Hydrolase activity, acting on carbon-nitrogen (but not peptide) bondsIEAmolecular_function
GO:0016812Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidesIEAmolecular_function
GO:0017144Drug metabolic processISSbiological_process
GO:0018107Peptidyl-threonine phosphorylationISSbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0031000Response to caffeineIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0035690Cellular response to drugIEAbiological_process
GO:0042802Identical protein bindingISSmolecular_function
GO:0042995Cell projectionISScellular_component
GO:0043025Neuronal cell bodyISScellular_component
GO:0043195Terminal boutonISScellular_component
GO:0043234Protein complexIEAcellular_component
GO:0044205'de novo' UMP biosynthetic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046134Pyrimidine nucleoside biosynthetic processTASbiological_process
GO:0046777Protein autophosphorylationISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051414Response to cortisolIEAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0070335Aspartate bindingISSmolecular_function
GO:0070409Carbamoyl phosphate biosynthetic processIEAbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26387867860.09269115920.95840357390.5800580124

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0770119087
GSE13712_SHEARUp0.2307883963
GSE13712_STATICUp0.1548169364
GSE19018Down-0.0697813201
GSE19899_A1Down-0.1819461569
GSE19899_A2Down-0.5014714629
PubMed_21979375_A1Up0.8119679956
PubMed_21979375_A2Up0.3014405287
GSE35957Down-0.5960972922
GSE36640Down-0.6412750070
GSE54402Up0.0475169016
GSE9593Down-0.2335331703
GSE43922Up0.0457458680
GSE24585Down-0.9808452140
GSE37065Down-0.5214869832
GSE28863_A1Up0.7783787495
GSE28863_A2Up1.0973236945
GSE28863_A3Down-0.1340097264
GSE28863_A4Down-0.1773311637
GSE48662Up0.1099314824

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Aspartic AcidDB00128 NUTR00016 | EXPT01823
Sparfosic acidDB03459 EXPT02494

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023598ProteomicsFunctional MTI (Weak)18668040
hsa-miR-34a-5pMIMAT0000255MIRT025309ProteomicsFunctional MTI (Weak)21566225
hsa-miR-26b-5pMIMAT0000083MIRT028960MicroarrayFunctional MTI (Weak)19088304
hsa-miR-455-3pMIMAT0004784MIRT037845CLASHFunctional MTI (Weak)23622248
hsa-miR-505-5pMIMAT0004776MIRT037941CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040681CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043489CLASHFunctional MTI (Weak)23622248
hsa-miR-301a-3pMIMAT0000688MIRT044218CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045293CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049353CLASHFunctional MTI (Weak)23622248
hsa-miR-3200-3pMIMAT0015085MIRT052821CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.