HCSGD entry for NANOG
1. General information
| Official gene symbol | NANOG |
|---|---|
| Entrez ID | 79923 |
| Gene full name | Nanog homeobox |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001158 | Enhancer sequence-specific DNA binding | IEA | molecular_function |
| GO:0001710 | Mesodermal cell fate commitment | IEA | biological_process |
| GO:0001714 | Endodermal cell fate specification | IDA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA ISS | molecular_function |
| GO:0005634 | Nucleus | IC IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0008283 | Cell proliferation | IMP | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008406 | Gonad development | IEA | biological_process |
| GO:0009790 | Embryo development | IEP | biological_process |
| GO:0009880 | Embryonic pattern specification | IEA | biological_process |
| GO:0010454 | Negative regulation of cell fate commitment | IEA | biological_process |
| GO:0010468 | Regulation of gene expression | IMP | biological_process |
| GO:0017145 | Stem cell division | IEA | biological_process |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEP | biological_process |
| GO:0030514 | Negative regulation of BMP signaling pathway | IEA | biological_process |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | IMP | biological_process |
| GO:0045595 | Regulation of cell differentiation | IMP | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7398547776 | 0.6825705026 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0165987681 |
| GSE13712_SHEAR | Up | 0.0176820947 |
| GSE13712_STATIC | Down | -0.0283563073 |
| GSE19018 | Up | 0.1679224686 |
| GSE19899_A1 | Up | 0.0264865636 |
| GSE19899_A2 | Up | 0.2615832629 |
| PubMed_21979375_A1 | Down | -0.0321245096 |
| PubMed_21979375_A2 | Up | 0.0045633061 |
| GSE35957 | Up | 0.0899422003 |
| GSE36640 | Up | 0.0566613850 |
| GSE54402 | Down | -0.0088745068 |
| GSE9593 | Down | -0.2451008822 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.1460367933 |
| GSE28863_A2 | Down | -0.1010727437 |
| GSE28863_A3 | Up | 0.3524546648 |
| GSE28863_A4 | Down | -0.1377991047 |
| GSE48662 | Down | -0.1701749558 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT006222 | Luciferase reporter assay//Western blot | Functional MTI | 22020437 |
| hsa-miR-34b-3p | MIMAT0004676 | MIRT006229 | Luciferase reporter assay//Western blot | Functional MTI | 22020437 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT006228 | Luciferase reporter assay//Western blot | Functional MTI | 22020437 |
| hsa-miR-181a-3p | MIMAT0000270 | MIRT007216 | Luciferase reporter assay | Functional MTI | 23344176 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017305 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT035522 | Luciferase reporter assay | Functional MTI | 23541921 |
| hsa-miR-320a | MIMAT0000510 | MIRT044412 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26860864 | In addition, polyploid cells were positive for markers of embryonic stemness (OCT4, SOX2, NANOG) and senescence (p16INK4a) |
| 26514209 | Syndecan-1 expression diminished, whereas stem cell markers such as SOX2, NANOG, OCT4, and E2F3 increased |
| 26102294 | SOX2 and NANOG expression did not change following ETO treatment suggesting a dissociation of OCT4A from its pluripotency function |
| 26089914 | For each early passage BM-MSC sample (5th or 6th passages), the normalized protein expression levels of senescence-associated markers p16(INK4A), p21(WAF1), SOD2, and rpS6(S240/244); the concentration of IL6 and IL8 in cell culture supernatants; and the normalized gene expression levels of pluripotency markers OCT4, NANOG, and SOX2 were correlated with final population doubling (PD) number |
| 25685943 | Magnetofection Mediated Transient NANOG Overexpression Enhances Proliferation and Myogenic Differentiation of Human Hair Follicle Derived Mesenchymal Stem Cells |
| 25685943 | Then we applied the optimized MF protocol to express the pluripotency-associated transcription factor NANOG, which was previously shown to reverse the effects of organismal aging on MSC proliferation and myogenic differentiation capacity |
| 25685943 | Indeed, MF-mediated NANOG delivery increased proliferation and enhanced the differentiation of hHF-MSCs into smooth muscle cells (SMCs) |
| 25279549 | The BORIS-positive cells isolated using BORIS-molecular beacon, expressed higher telomerase hTERT, stem cell (NANOG, OCT4, SOX2) and cancer stem cell marker genes (CD44 and ALDH1) compared to the BORIS-negative tumor cells |
| 21629737 | Further, with development of senescence and accumulation of p16inka4a and p21CIP1, NANOG is downregulated in most cells |
| 21562774 | They showed alkaline phosphatase activity and expressed ESC markers, as shown by immunostaining of OCT4, SOX2, SSEA4, and TRA-1-81 as well as reverse-transcription polymerase chain reaction (RT-PCR) for OCT4 and NANOG transcripts |
| 20457152 | Here, we studied the role of the pluripotency and self-renewal stem cell genes NANOG, OCT4 and SOX2 in this polyploidy-dependent survival mechanism |
| 20457152 | In irradiation-resistant p53-mutated lymphoma cell-lines (Namalwa and WI-L2-NS) but not sensitive p53 wild-type counterparts (TK6), low background expression of OCT4 and NANOG was up-regulated by ionising radiation with protein accumulation evident in ETC as detected by OCT4/DNA flow cytometry and immunofluorescence (IF) |
| 20457152 | IF analysis also showed that the ETC generate PML bodies that appear to concentrate OCT4, NANOG and SOX2 proteins, which extend into complex nuclear networks |
| 20457152 | These polyploid tumour cells resist apoptosis, overcome cellular senescence and undergo bi- and multi-polar divisions transmitting the up-regulated OCT4, NANOG and SOX2 self-renewal cassette to their descendents |
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