HCSGD entry for NR4A3

1. General information

Official gene symbolNR4A3
Entrez ID8013
Gene full namenuclear receptor subfamily 4, group A, member 3
Other gene symbolsCHN CSMF MINOR NOR1 TEC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001707Mesoderm formationIEAbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004887Thyroid hormone receptor activityTASmolecular_function
GO:0005634NucleusNAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0008150Biological_processNDbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0030534Adult behaviorIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0048752Semicircular canal morphogenesisIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0060005Vestibular reflexIEAbiological_process
GO:2000108Positive regulation of leukocyte apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01591320620.76796090950.31187751301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-2.2419383568
GSE13712_SHEARUp0.0902592468
GSE13712_STATICUp0.0179633504
GSE19018Up0.1613544257
GSE19899_A1Up0.2602730897
GSE19899_A2Up0.6814732584
PubMed_21979375_A1Up2.0821258196
PubMed_21979375_A2Up1.0077088909
GSE35957Down-0.0826032053
GSE36640Up0.2251811286
GSE54402Up0.5643801040
GSE9593Down-0.5716700353
GSE43922Up0.5581291178
GSE24585Down-0.2164470743
GSE37065Up0.8361544017
GSE28863_A1Up0.2189619048
GSE28863_A2Up0.0945766348
GSE28863_A3Up0.1473506924
GSE28863_A4Up0.0739034720
GSE48662Down-0.1317936144

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022644MicroarrayFunctional MTI (Weak)18668037
hsa-miR-10b-5pMIMAT0000254MIRT025586Reporter assayNon-Functional MTI21642433
hsa-miR-26b-5pMIMAT0000083MIRT029401MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15574883In addition to DUSP1 and known p53 and E2F targets, a number of genes such as PHLDA1, NR4A3, and a novel splice variant of STAC were implicated in senescence
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