HCSGD entry for TSEN2
1. General information
| Official gene symbol | TSEN2 |
|---|---|
| Entrez ID | 80746 |
| Gene full name | tRNA splicing endonuclease 2 homolog (S. cerevisiae) |
| Other gene symbols | PCH2B SEN2 SEN2L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000213 | TRNA-intron endonuclease activity | IEA | molecular_function |
| GO:0000214 | TRNA-intron endonuclease complex | IEA | cellular_component |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006388 | TRNA splicing, via endonucleolytic cleavage and ligation | IDA IEA | biological_process |
| GO:0006397 | MRNA processing | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9007672809 | 0.2032777516 | 0.9999902473 | 0.8734041299 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0615381665 |
| GSE13712_SHEAR | Up | 0.1604689910 |
| GSE13712_STATIC | Up | 0.2226430756 |
| GSE19018 | Down | -0.2395199028 |
| GSE19899_A1 | Down | -0.0683581249 |
| GSE19899_A2 | Up | 0.2630547249 |
| PubMed_21979375_A1 | Down | -0.0958947409 |
| PubMed_21979375_A2 | Up | 0.1063292949 |
| GSE35957 | Down | -0.1179040643 |
| GSE36640 | Down | -0.2134234730 |
| GSE54402 | Down | -0.2099291057 |
| GSE9593 | Down | -0.1710244917 |
| GSE43922 | Up | 0.0087644368 |
| GSE24585 | Down | -0.8569756625 |
| GSE37065 | Down | -0.1437783391 |
| GSE28863_A1 | Up | 0.0733984398 |
| GSE28863_A2 | Up | 0.0160136306 |
| GSE28863_A3 | Down | -0.0088864776 |
| GSE28863_A4 | Up | 0.0173936094 |
| GSE48662 | Down | -0.1559472650 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043908 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
