HCSGD entry for KMT2D
1. General information
| Official gene symbol | KMT2D |
|---|---|
| Entrez ID | 8085 |
| Gene full name | lysine (K)-specific methyltransferase 2D |
| Other gene symbols | AAD10 ALR CAGL114 KABUK1 KMS MLL2 MLL4 TNRC21 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001555 | Oocyte growth | IEA ISS | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA NAS | cellular_component |
| GO:0006342 | Chromatin silencing | IEA ISS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0008168 | Methyltransferase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IEA | molecular_function |
| GO:0033148 | Positive regulation of intracellular estrogen receptor signaling pathway | IMP | biological_process |
| GO:0035097 | Histone methyltransferase complex | IPI | cellular_component |
| GO:0043627 | Response to estrogen | IDA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0048477 | Oogenesis | ISS | biological_process |
| GO:0051568 | Histone H3-K4 methylation | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1074593746 | 0.9362744273 | 0.6807312154 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0264193200 |
| GSE13712_SHEAR | Up | 0.4814841912 |
| GSE13712_STATIC | Up | 0.1304268444 |
| GSE19018 | Down | -0.2856367022 |
| GSE19899_A1 | Up | 0.1941150812 |
| GSE19899_A2 | Up | 0.2248848785 |
| PubMed_21979375_A1 | Down | -0.0489424480 |
| PubMed_21979375_A2 | Up | 0.1099184787 |
| GSE35957 | Up | 0.0211974897 |
| GSE36640 | Up | 0.1448836260 |
| GSE54402 | Up | 0.2323833489 |
| GSE9593 | Down | -0.0031774771 |
| GSE43922 | Up | 0.1903815856 |
| GSE24585 | Down | -0.3468162171 |
| GSE37065 | Up | 0.1247162322 |
| GSE28863_A1 | Up | 0.6718013267 |
| GSE28863_A2 | Up | 0.5092152265 |
| GSE28863_A3 | Down | -0.0772148797 |
| GSE28863_A4 | Down | -0.0590614376 |
| GSE48662 | Up | 0.2847952897 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020244 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021140 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021394 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025558 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028093 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028093 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036326 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1224-3p | MIMAT0005459 | MIRT036547 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-760 | MIMAT0004957 | MIRT036755 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037311 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037627 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039045 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039869 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040527 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040931 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042681 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044297 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044425 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045979 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046526 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046827 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047911 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049163 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT050025 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
