HCSGD entry for SLC7A5
1. General information
| Official gene symbol | SLC7A5 |
|---|---|
| Entrez ID | 8140 |
| Gene full name | solute carrier family 7 (amino acid transporter light chain, L system), member 5 |
| Other gene symbols | 4F2LC CD98 D16S469E E16 LAT1 MPE16 hLAT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006520 | Cellular amino acid metabolic process | TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0006865 | Amino acid transport | TAS | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0015171 | Amino acid transmembrane transporter activity | ISS | molecular_function |
| GO:0015175 | Neutral amino acid transmembrane transporter activity | TAS | molecular_function |
| GO:0015179 | L-amino acid transmembrane transporter activity | IEA | molecular_function |
| GO:0015804 | Neutral amino acid transport | ISS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0042605 | Peptide antigen binding | ISS | molecular_function |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0652632613 | 0.0384740435 | 0.5505750962 | 0.3692877871 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.8762691250 |
| GSE13712_SHEAR | Up | 0.9389867901 |
| GSE13712_STATIC | Up | 0.1324496046 |
| GSE19018 | Up | 1.0545803305 |
| GSE19899_A1 | Down | -0.0457386995 |
| GSE19899_A2 | Down | -0.3862546361 |
| PubMed_21979375_A1 | Up | 2.0455223952 |
| PubMed_21979375_A2 | Up | 0.3830250634 |
| GSE35957 | Down | -0.7326428816 |
| GSE36640 | Down | -0.8520199941 |
| GSE54402 | Down | -0.6878828029 |
| GSE9593 | Up | 0.2020391823 |
| GSE43922 | Up | 0.4813250364 |
| GSE24585 | Up | 0.0269176735 |
| GSE37065 | Down | -0.0885327915 |
| GSE28863_A1 | Down | -0.2407016102 |
| GSE28863_A2 | Up | 0.1242554908 |
| GSE28863_A3 | Down | -0.1433372529 |
| GSE28863_A4 | Down | -0.1637548412 |
| GSE48662 | Down | -0.0363995771 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-626 | MIMAT0003295 | MIRT004144 | Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blot//Immunoprecipitation | Non-Functional MTI | 19892711 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT004528 | Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blot//Immunoprecipitation | Functional MTI | 19892711 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT006679 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21439283 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016508 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031833 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038496 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039269 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | 1 | hsa-miR-7 | {Western blot} | {overexpression by miRNA precursor transfection} | 19892711 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
