HCSGD entry for ITM2C
1. General information
| Official gene symbol | ITM2C |
|---|---|
| Entrez ID | 81618 |
| Gene full name | integral membrane protein 2C |
| Other gene symbols | BRI3 BRICD2C E25 E25C ITM3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001540 | Beta-amyloid binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005764 | Lysosome | IDA IEA ISS | cellular_component |
| GO:0005765 | Lysosomal membrane | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0010977 | Negative regulation of neuron projection development | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030182 | Neuron differentiation | IDA ISS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1629354774 | 0.0355427985 | 0.7990729830 | 0.3571019466 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3662040431 |
| GSE13712_SHEAR | Down | -0.6396857084 |
| GSE13712_STATIC | Down | -0.6900671673 |
| GSE19018 | Up | 0.4383799597 |
| GSE19899_A1 | Up | 0.2810159519 |
| GSE19899_A2 | Up | 0.3539351388 |
| PubMed_21979375_A1 | Down | -0.5576838759 |
| PubMed_21979375_A2 | Up | 0.1323967602 |
| GSE35957 | Down | -1.4756162718 |
| GSE36640 | Up | 0.9813936414 |
| GSE54402 | Down | -0.6741425723 |
| GSE9593 | Down | -0.1344969318 |
| GSE43922 | Down | -0.0162544939 |
| GSE24585 | Up | 0.3783644326 |
| GSE37065 | Down | -1.0473987380 |
| GSE28863_A1 | Up | 0.1143443723 |
| GSE28863_A2 | Up | 0.3909395040 |
| GSE28863_A3 | Up | 0.3530458576 |
| GSE28863_A4 | Down | -0.5006061176 |
| GSE48662 | Up | 0.5267290176 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027070 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036807 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040849 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043113 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
