HCSGD entry for MAP1LC3B
1. General information
| Official gene symbol | MAP1LC3B |
|---|---|
| Entrez ID | 81631 |
| Gene full name | microtubule-associated protein 1 light chain 3 beta |
| Other gene symbols | ATG8F LC3B MAP1A/1BLC3 MAP1LC3B-a |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000421 | Autophagic vacuole membrane | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005776 | Autophagic vacuole | ISS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0005930 | Axoneme | ISS | cellular_component |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0031090 | Organelle membrane | ISS | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0008838152 | 0.9991774819 | 0.0816242105 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3696823704 |
| GSE13712_SHEAR | Up | 0.3833501966 |
| GSE13712_STATIC | Up | 0.3642366557 |
| GSE19018 | Up | 0.2759016490 |
| GSE19899_A1 | Up | 1.0085379570 |
| GSE19899_A2 | Up | 1.2442844571 |
| PubMed_21979375_A1 | Up | 1.3177259784 |
| PubMed_21979375_A2 | Up | 1.1058848370 |
| GSE35957 | Up | 0.3576483525 |
| GSE36640 | Up | 1.6175334302 |
| GSE54402 | Up | 0.4606316924 |
| GSE9593 | Up | 0.9728768025 |
| GSE43922 | Up | 0.5474649491 |
| GSE24585 | Up | 0.4446344125 |
| GSE37065 | Up | 0.1048328571 |
| GSE28863_A1 | Up | 0.2027474836 |
| GSE28863_A2 | Up | 0.5570297278 |
| GSE28863_A3 | Down | -0.0662242471 |
| GSE28863_A4 | Up | 0.0003473132 |
| GSE48662 | Down | -0.0825121316 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT006449 | Immunoblot//Immunofluorescence//qRT-PCR//Western blot | Functional MTI | 22516261 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018460 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024923 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026738 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028590 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25895748 | Biopsies of CXPA (ex vivo) allowed immunhistochemical evaluation of p21 and p16, whilst LC3B, p21 and p16 protein expression was analyzed by western blotting |
| 25895748 | In the in vitro model, the myoepithelial cells were positive for LC3B (cytoplasm) and p21 (nucleus), whilst in vivo positivity for p21 and p16 was observed |
| 25895748 | Western blotting analysis revealed an increased LC3B, p16 and p21 expression in the myoepithelial cells with previous contact with the malignant cells when compared with those without contact |
| 25077541 | We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, and HIF1alpha, and downregulating mTOR, c-myc, cyclin D1, and JNK |
| 24367027 | Autophagy inhibition by knockdown of ATG5 and LC3B attenuated the antisenescent effect of SIRT6 overexpression |
| 22627293 | Conversely, drug-treated cells were characterized by the occurrence of typical biochemical and morphological features associated with autophagy, such as an increase in the lipidated form of the autophagic marker LC3B and the accumulation of autophagosomes |
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