HCSGD entry for BAP1
1. General information
| Official gene symbol | BAP1 |
|---|---|
| Entrez ID | 8314 |
| Gene full name | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) |
| Other gene symbols | HUCEP-13 UCHL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001558 | Regulation of cell growth | IMP | biological_process |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IEA IMP | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006464 | Cellular protein modification process | NAS | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008233 | Peptidase activity | NAS | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0016579 | Protein deubiquitination | IDA | biological_process |
| GO:0035517 | PR-DUB complex | IDA | cellular_component |
| GO:0035522 | Monoubiquitinated histone H2A deubiquitination | IDA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0051726 | Regulation of cell cycle | IMP | biological_process |
| GO:0071108 | Protein K48-linked deubiquitination | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1757638046 | 0.5880561187 | 0.8230634762 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3307732341 |
| GSE13712_SHEAR | Down | -0.3258286393 |
| GSE13712_STATIC | Down | -0.1131785804 |
| GSE19018 | Down | -0.0462337078 |
| GSE19899_A1 | Down | -0.1742757623 |
| GSE19899_A2 | Up | 0.0727433673 |
| PubMed_21979375_A1 | Up | 0.5066635460 |
| PubMed_21979375_A2 | Up | 0.4453958723 |
| GSE35957 | Down | -0.3750259084 |
| GSE36640 | Down | -0.4034275923 |
| GSE54402 | Up | 0.1166813916 |
| GSE9593 | Up | 0.0363134692 |
| GSE43922 | Up | 0.0017477126 |
| GSE24585 | Down | -0.1410128284 |
| GSE37065 | Down | -0.1847347206 |
| GSE28863_A1 | Up | 0.5043181921 |
| GSE28863_A2 | Up | 0.3888784940 |
| GSE28863_A3 | Up | 0.3760371462 |
| GSE28863_A4 | Down | -0.0570958863 |
| GSE48662 | Up | 0.4688270472 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000724 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000724 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT000726 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT000726 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT000727 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT000727 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT000730 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT000730 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-429 | MIMAT0001536 | MIRT016637 | Reporter assay | Functional MTI | 20005803 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036361 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037201 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038727 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
