HCSGD entry for CASP1
1. General information
| Official gene symbol | CASP1 |
|---|---|
| Entrez ID | 834 |
| Gene full name | caspase 1, apoptosis-related cysteine peptidase |
| Other gene symbols | ICE IL1BC P45 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0004197 | Cysteine-type endopeptidase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IDA IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA TAS | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | TAS | molecular_function |
| GO:0010952 | Positive regulation of peptidase activity | TAS | biological_process |
| GO:0016485 | Protein processing | IEA | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0032611 | Interleukin-1 beta production | IEA | biological_process |
| GO:0033198 | Response to ATP | IEA | biological_process |
| GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
| GO:0042981 | Regulation of apoptotic process | IEA | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IEP | biological_process |
| GO:0043281 | Regulation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050717 | Positive regulation of interleukin-1 alpha secretion | IEA | biological_process |
| GO:0050718 | Positive regulation of interleukin-1 beta secretion | IEA | biological_process |
| GO:0050727 | Regulation of inflammatory response | IEA | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0051882 | Mitochondrial depolarization | IEA | biological_process |
| GO:0052547 | Regulation of peptidase activity | TAS | biological_process |
| GO:0060081 | Membrane hyperpolarization | IEA | biological_process |
| GO:0070269 | Pyroptosis | IEA | biological_process |
| GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
| GO:0071310 | Cellular response to organic substance | IDA | biological_process |
| GO:0072557 | IPAF inflammasome complex | ISS | cellular_component |
| GO:0072558 | NLRP1 inflammasome complex | IDA | cellular_component |
| GO:0072559 | NLRP3 inflammasome complex | IDA | cellular_component |
| GO:0097169 | AIM2 inflammasome complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8528504730 | 0.0004178945 | 0.9999902473 | 0.0381954861 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1588723225 |
| GSE13712_SHEAR | Up | 0.2657361600 |
| GSE13712_STATIC | Up | 0.5699276358 |
| GSE19018 | Down | -0.5159071253 |
| GSE19899_A1 | Down | -1.3936554575 |
| GSE19899_A2 | Down | -3.0255001976 |
| PubMed_21979375_A1 | Down | -3.3996559063 |
| PubMed_21979375_A2 | Down | -2.2963040565 |
| GSE35957 | Down | -0.7402488872 |
| GSE36640 | Down | -0.6956847953 |
| GSE54402 | Down | -1.9755650443 |
| GSE9593 | Down | -0.4493473665 |
| GSE43922 | Down | -1.7910170978 |
| GSE24585 | Down | -0.0152868250 |
| GSE37065 | Up | 0.9329231157 |
| GSE28863_A1 | Down | -0.2683485908 |
| GSE28863_A2 | Down | -0.0002109490 |
| GSE28863_A3 | Up | 0.1403466346 |
| GSE28863_A4 | Down | -0.1087209413 |
| GSE48662 | Down | -0.2036502133 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Minocycline | DB01017 | APRD00547 |
| Pralnacasan | DB04875 | - |
| LAX-101 | DB05301 | - |
| IDN-6556 | DB05408 | - |
| VX-765 | DB05507 | - |
| 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE | DB07733 | - |
| 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID | DB07744 | - |
| 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID | DB07916 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27579045 | Despite the enhanced cell viability at later passages (P4-5), the expression of senescence marker, beta-galactosidase, was significantly increased at passage 5 |
| 19342460 | Unexpectedly, these changes were independent of changes in proliferation rate within the hyperplastic tissue, suggesting that endogenous SST controls GHRH-induced adenoma formation primarily via modulation of apoptotic and/or cellular senescence pathways, consistent with the predicted function of some of the most differentially expressed genes (Casp1, MAP2K1, TNFR2) identified by membrane arrays and confirmed by quantitative real-time RT-PCR |
| 15668299 | Studies with Deltayca1 and Deltagsh1 deletion mutants indicate that ROS accumulation as well as the presence of yeast caspase 1 is needed for apoptosis in toxin-treated yeast cells |
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