HCSGD entry for RASSF5
1. General information
| Official gene symbol | RASSF5 |
|---|---|
| Entrez ID | 83593 |
| Gene full name | Ras association (RalGDS/AF-6) domain family member 5 |
| Other gene symbols | Maxp1 NORE1 NORE1A NORE1B RAPL RASSF3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0031398 | Positive regulation of protein ubiquitination | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7655121462 | 0.5472855743 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0443643549 |
| GSE13712_SHEAR | Down | -0.0350642439 |
| GSE13712_STATIC | Down | -0.0790798864 |
| GSE19018 | Up | 0.0108169908 |
| GSE19899_A1 | Up | 0.1961754650 |
| GSE19899_A2 | Down | -0.2186268717 |
| PubMed_21979375_A1 | Up | 0.1385181270 |
| PubMed_21979375_A2 | Down | -0.1393894725 |
| GSE35957 | Up | 0.1048375289 |
| GSE36640 | Up | 0.1931771720 |
| GSE54402 | Down | -0.1784392527 |
| GSE9593 | Down | -0.0806695369 |
| GSE43922 | Up | 0.0387208605 |
| GSE24585 | Down | -0.2390013301 |
| GSE37065 | Up | 0.1840178132 |
| GSE28863_A1 | Down | -0.0075523605 |
| GSE28863_A2 | Up | 0.1013324642 |
| GSE28863_A3 | Up | 0.1497660574 |
| GSE28863_A4 | Down | -0.0193912214 |
| GSE48662 | Down | -0.1482470774 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002619 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002619 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017885 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023792 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-374b-5p | MIMAT0004955 | MIRT036802 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041417 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26677227 | Ras Regulates Rb via NORE1A |
| 26677227 | We have shown recently that the Ras death effector NORE1A plays a critical role in promoting Ras-induced senescence and connects Ras to the regulation of the p53 tumor suppressor |
| 26677227 | We now show that NORE1A also connects Ras to the regulation of a second major prosenescent tumor suppressor, the retinoblastoma (Rb) protein |
| 26677227 | We show that Ras induces the formation of a complex between NORE1A and the phosphatase PP1A, promoting the activation of the Rb tumor suppressor by dephosphorylation |
| 26677227 | Furthermore, suppression of Rb reduces NORE1A senescence activity |
| 26677227 | These results, together with our previous findings, suggest that NORE1A acts as a critical tumor suppressor node, linking Ras to both the p53 and the Rb pathways to drive senescence |
Entries Per Page
Displaying Page of
