HCSGD entry for ITCH

1. General information

Official gene symbolITCH
Entrez ID83737
Gene full nameitchy E3 ubiquitin protein ligase
Other gene symbolsAIF4 AIP4 NAPP1 dJ468O1.1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001558Regulation of cell growthNASbiological_process
GO:0002669Positive regulation of T cell anergyIEAbiological_process
GO:0004842Ubiquitin-protein ligase activityIDA NAS TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIBAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIDA NASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006954Inflammatory responseNASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0031410Cytoplasmic vesicleIEAcellular_component
GO:0032088Negative regulation of NF-kappaB transcription factor activityISSbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0035519Protein K29-linked ubiquitinationIDAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIBAbiological_process
GO:0043021Ribonucleoprotein complex bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045236CXCR chemokine receptor bindingIPImolecular_function
GO:0045732Positive regulation of protein catabolic processIEAbiological_process
GO:0046329Negative regulation of JNK cascadeISSbiological_process
GO:0046642Negative regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0046718Viral entry into host cellTASbiological_process
GO:0050687Negative regulation of defense response to virusIMPbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070534Protein K63-linked ubiquitinationIDAbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0090085Regulation of protein deubiquitinationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33666987580.46596917290.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2484926622
GSE13712_SHEARDown-0.0402021723
GSE13712_STATICUp0.0219711341
GSE19018Up0.1601100430
GSE19899_A1Up0.0821183574
GSE19899_A2Down-0.3117379803
PubMed_21979375_A1Down-0.0361373405
PubMed_21979375_A2Down-0.5333412307
GSE35957Down-0.0874988407
GSE36640Down-0.1222705269
GSE54402Up0.0798881135
GSE9593Up0.1211982016
GSE43922Down-0.0423622737
GSE24585Up0.4797343356
GSE37065Down-0.1291296796
GSE28863_A1Up0.6882258621
GSE28863_A2Up0.3643164763
GSE28863_A3Down-0.0098695680
GSE28863_A4Up0.1064767633
GSE48662Down-0.2533046298

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106b-5pMIMAT0000680MIRT000372Luciferase reporter assayFunctional MTI19074548
hsa-miR-106b-5pMIMAT0000680MIRT000372Luciferase reporter assay//Western blotFunctional MTI19096009
hsa-miR-106b-5pMIMAT0000680MIRT000372MicroarrayFunctional MTI (Weak)17242205
hsa-miR-324-3pMIMAT0000762MIRT042842CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-106b-5pMIMAT00006801hsa-miR-106b{Western blot}{overexpression by miRNA precursor transfection}19096009
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.