HCSGD entry for CASP8

1. General information

Official gene symbolCASP8
Entrez ID841
Gene full namecaspase 8, apoptosis-related cysteine peptidase
Other gene symbolsALPS2B CAP4 Casp-8 FLICE MACH MCH5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001841Neural tube formationIEAbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004197Cysteine-type endopeptidase activityIDA IEA TASmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDA IEAcellular_component
GO:0005741Mitochondrial outer membraneTAScellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0006508ProteolysisIDA IEAbiological_process
GO:0006915Apoptotic processIEA IGI IMP TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEA TASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008233Peptidase activityIMPmolecular_function
GO:0008234Cysteine-type peptidase activityTASmolecular_function
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:0009409Response to coldIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0030101Natural killer cell activationTASbiological_process
GO:0030225Macrophage differentiationIEA TASbiological_process
GO:0030690Noc1p-Noc2p complexIEAcellular_component
GO:0031264Death-inducing signaling complexIDAcellular_component
GO:0031265CD95 death-inducing signaling complexIEAcellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032025Response to cobalt ionIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034612Response to tumor necrosis factorIMPbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0042113B cell activationTASbiological_process
GO:0042981Regulation of apoptotic processIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEP IMPbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0044297Cell bodyIEAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045471Response to ethanolIEAbiological_process
GO:0045651Positive regulation of macrophage differentiationIMPbiological_process
GO:0045862Positive regulation of proteolysisIDAbiological_process
GO:0046677Response to antibioticIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051603Proteolysis involved in cellular protein catabolic processIMPbiological_process
GO:0060715Syncytiotrophoblast cell differentiation involved in labyrinthine layer developmentTASbiological_process
GO:0070243Regulation of thymocyte apoptotic processIEAbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0097153Cysteine-type endopeptidase activity involved in apoptotic processIEA IMPmolecular_function
GO:0097190Apoptotic signaling pathwayIMP TASbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:0097194Execution phase of apoptosisIMPbiological_process
GO:0097202Activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0097284Hepatocyte apoptotic processIEAbiological_process
GO:0097342RipoptosomeIDAcellular_component
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13039453290.90123447820.73335779911.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1542766687
GSE13712_SHEARUp0.2927544217
GSE13712_STATICUp0.3030520660
GSE19018Up0.1851215944
GSE19899_A1Up0.1043057427
GSE19899_A2Up0.6196786544
PubMed_21979375_A1Up0.2123101353
PubMed_21979375_A2Up0.0855788170
GSE35957Down-0.0886146572
GSE36640Down-0.3637330608
GSE54402Up0.1087179622
GSE9593Down-0.1766236584
GSE43922Up0.1410511901
GSE24585Up0.5647762081
GSE37065Up0.1312942737
GSE28863_A1Down-0.0027372494
GSE28863_A2Down-0.0605128412
GSE28863_A3Up0.0972093342
GSE28863_A4Down-0.0994692870
GSE48662Down-0.0469131611

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-19b-1-5pMIMAT0004491MIRT006278Luciferase reporter assayNon-Functional MTI22197821
hsa-let-7a-5pMIMAT0000062MIRT005293Western blotNon-Functional MTI18758960
hsa-miR-26b-5pMIMAT0000083MIRT029158MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27212655This resistance occurred via caspase-9 and caspase-3 rather than via caspase-8
23238821The apoptosis and senescence of NP cells was investigated by terminal deoxyribonucleotidyl transferase (TDT)-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay, immunohistochemistry, and Western blot for caspase3, caspase8, caspase9, and p16lnk4A (increased in cellular senescence)
23238821Diabetes increased apoptosis of NP cells and led to activations of initiators of intrinsic (caspases-9) and extrinsic (caspase-8) pathways as well as their common executioner (caspase-3)
12473065Similarities between preparations included: an enhanced ability for both Apo2L/TRAIL preparations to kill a greater relative percentage of HaCaT cells compared with keratinocytes; enhanced cytotoxicity towards keratinocytes that had their NF-B activity inhibited; a dependence of both Apo2L/TRAIL preparations on FADD and caspase activation; triggering of the same caspase cascades including caspase 8 and 3; and an ability to induce apoptosis even when HaCaT cells and keratinocytes were transduced to overexpress either Bcl-2 or Bcl-x(L) (survival factors that reduce susceptibility to UV-light-induced apoptosis)
11857449We suggest a model whereby SV40-transformed cells acquire increased sensitivity to apoptosis based on changes in properties which activate caspase 8 in addition to changes previously described involving shortening of telomeric sequences
10438583These results suggest that Bcl-2 blocked Fas-mediated cell death by acting downstream of caspase-8, which is in contrast to staurosporine-induced apoptosis where Bcl-2 is acting upstream of caspase-8
Entries Per Page
Displaying Page of