HCSGD entry for TXNDC2

1. General information

Official gene symbolTXNDC2
Entrez ID84203
Gene full namethioredoxin domain containing 2 (spermatozoa)
Other gene symbolsSPTRX SPTRX1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001520Outer dense fiberIEAcellular_component
GO:0003756Protein disulfide isomerase activityIEAmolecular_function
GO:0004791Thioredoxin-disulfide reductase activityIDA ISSmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0006662Glycerol ether metabolic processIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007283SpermatogenesisNASbiological_process
GO:0015035Protein disulfide oxidoreductase activityIEAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0031514Motile ciliumIEAcellular_component
GO:0045454Cell redox homeostasisIEA NASbiological_process
GO:0045735Nutrient reservoir activityIEAmolecular_function
GO:0055114Oxidation-reduction processIDA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47790843050.78768753470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0939194462
GSE13712_SHEARUp0.1653736061
GSE13712_STATICUp0.0190413941
GSE19018Up0.0599310641
GSE19899_A1Up0.1588038138
GSE19899_A2Up0.0882012157
PubMed_21979375_A1Down-0.0162910214
PubMed_21979375_A2Up0.0355447786
GSE35957Up0.1223572830
GSE36640Down-0.0650246783
GSE54402Up0.2720908736
GSE9593Up0.0181557643
GSE43922Up0.0287497301
GSE24585Down-0.5878941829
GSE37065Up0.2663504728
GSE28863_A1Up0.0095326459
GSE28863_A2Down-0.0361288327
GSE28863_A3Down-0.0639800186
GSE28863_A4Up0.1063842167
GSE48662Down-0.0586753289

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23763475H2 O2 increased the expression of stress defence genes, including catalase, cytochrome B alpha, lactoperoxidase and thioredoxin domain containing 2
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