HCSGD entry for C2orf40
1. General information
| Official gene symbol | C2orf40 |
|---|---|
| Entrez ID | 84417 |
| Gene full name | chromosome 2 open reading frame 40 |
| Other gene symbols | ECRG4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0008054 | Cyclin catabolic process | IEA | biological_process |
| GO:0030133 | Transport vesicle | IEA | cellular_component |
| GO:0070314 | G1 to G0 transition | IEA | biological_process |
| GO:0090398 | Cellular senescence | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5196147677 | 0.8911190380 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0724302196 |
| GSE13712_SHEAR | Down | -0.0456281737 |
| GSE13712_STATIC | Down | -0.1405911431 |
| GSE19018 | Up | 0.0032828851 |
| GSE19899_A1 | Up | 0.1849693224 |
| GSE19899_A2 | Up | 0.1705794667 |
| PubMed_21979375_A1 | Down | -0.0523675604 |
| PubMed_21979375_A2 | Up | 0.1562757612 |
| GSE35957 | Down | -0.1622645742 |
| GSE36640 | Down | -0.0025226477 |
| GSE54402 | Up | 0.1501296274 |
| GSE9593 | Down | -0.0645210869 |
| GSE43922 | Up | 0.0157161683 |
| GSE24585 | Up | 0.2252483596 |
| GSE37065 | Up | 0.0654070366 |
| GSE28863_A1 | Down | -0.1513238219 |
| GSE28863_A2 | Up | 0.0327311576 |
| GSE28863_A3 | Up | 0.1141104619 |
| GSE28863_A4 | Up | 0.0590719354 |
| GSE48662 | Up | 0.1125670460 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22899245 | The candidate tumor suppressor gene Ecrg4 as a wound terminating factor in cutaneous injury |
| 22899245 | The Esophageal cancer-related gene-4 (Ecrg4) is a candidate tumor suppressor gene whose secreted protein product has been implicated in the development and progression of epithelial cancers, neuroprogenitor cell activation after central nervous system injury, cell senescence in neurodegeneration, and the survival of hematopoietic stem cells |
| 22899245 | Here, we investigated the temporal and spatial localization of Ecrg4 expression in healthy and injured mouse skin, and evaluated the biological activity of Ecrg4 using viral-mediated gene delivery in cutaneous wound healing models |
| 22899245 | Using in situ hybridization and immunohistochemistry, we found both Ecrg4 mRNA and its protein product localized to the epidermis, dermis, and hair follicles of healthy mouse skin |
| 22899245 | Upon cutaneous injury, Ecrg4 redistributed to the wound margins where gene microarray and quantitative RT-PCR showed an increased gene expression 5-10 days post-injury as a late phase injury response gene |
| 22899245 | Ecrg4 over-expression inhibited the directional migration of fibroblasts in modified Boyden chambers in vitro, but had no effect on rates of fibroblast proliferation |
| 22899245 | Ecrg4 over-expression in vivo at the wound margins delayed the rate of wound closure at 1 and 2 days after full-thickness punch injury |
| 22899245 | These findings point to the candidate tumor suppressor gene Ecrg4 as a novel, biologically active, constituent of skin and skin injury |
| 22899245 | The possibility that Ecrg4 serves as a wound termination factor during wound resolution is discussed |
| 20404145 | Here, using a serum-induced mouse oligodendrocyte precursor cell (mOPC) senescence model, we identified esophageal cancer-related gene 4 (Ecrg4) as a senescence inducer with implications for the senescence-like state of postmitotic cells in the aging brain |
| 20404145 | We show that Ecrg4 was up-regulated in the senescent OPCs, its overexpression in OPCs induced senescence by accelerating the proteasome-dependent degradation of cyclins D1 and D3, and that its knockdown by a specific short hairpin RNA prevented these phenotypes |
| 20404145 | We also show that senescent OPCs secreted Ecrg4 and that recombinant Ecrg4 induced OPC senescence in culture |
| 20404145 | Moreover, increased Ecrg4 expression was observed in the OPCs and neural precursor cells in the aged mouse brain; this was accompanied by the expression of senescence-associated beta-galactosidase activity, indicating the cells' entrance into senescence |
| 20404145 | These results suggest that Ecrg4 is a factor linking neural-cell senescence and aging |
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