HCSGD entry for CUL2
1. General information
| Official gene symbol | CUL2 |
|---|---|
| Entrez ID | 8453 |
| Gene full name | cullin 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0030891 | VCB complex | IEA | cellular_component |
| GO:0031461 | Cullin-RING ubiquitin ligase complex | IEA | cellular_component |
| GO:0031462 | Cul2-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IDA IEA | molecular_function |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0061418 | Regulation of transcription from RNA polymerase II promoter in response to hypoxia | TAS | biological_process |
| GO:0071456 | Cellular response to hypoxia | TAS | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3907454010 | 0.1546480035 | 0.9999902473 | 0.7601288702 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0559090049 |
| GSE13712_SHEAR | Up | 0.0891511816 |
| GSE13712_STATIC | Up | 0.2924748832 |
| GSE19018 | Down | -0.8817385084 |
| GSE19899_A1 | Up | 0.2675617080 |
| GSE19899_A2 | Up | 0.1980907864 |
| PubMed_21979375_A1 | Up | 0.0412813592 |
| PubMed_21979375_A2 | Down | -0.0583024624 |
| GSE35957 | Up | 0.3837065600 |
| GSE36640 | Down | -0.6089369109 |
| GSE54402 | Up | 0.4284772444 |
| GSE9593 | Down | -0.1359546301 |
| GSE43922 | Up | 0.1454420527 |
| GSE24585 | Down | -0.2183261374 |
| GSE37065 | Down | -0.1197214455 |
| GSE28863_A1 | Down | -0.1794200065 |
| GSE28863_A2 | Up | 0.0962491114 |
| GSE28863_A3 | Down | -0.4339992977 |
| GSE28863_A4 | Up | 0.1895747060 |
| GSE48662 | Down | -0.6999424320 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-424-5p | MIMAT0001341 | MIRT005927 | ChIP-seq//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 20972335 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT007130 | qRT-PCR | Functional MTI (Weak) | 23418453 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038756 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048406 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048623 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052315 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-4326 | MIMAT0016888 | MIRT052839 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
