HCSGD entry for LMNB2
1. General information
| Official gene symbol | LMNB2 |
|---|---|
| Entrez ID | 84823 |
| Gene full name | lamin B2 |
| Other gene symbols | LAMB2 LMN2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005635 | Nuclear envelope | IEA | cellular_component |
| GO:0005637 | Nuclear inner membrane | IEA | cellular_component |
| GO:0005638 | Lamin filament | IEA | cellular_component |
| GO:0005882 | Intermediate filament | IEA | cellular_component |
| GO:0008150 | Biological_process | ND | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8307396945 | 0.0035508073 | 0.9999902473 | 0.1210632124 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3895713935 |
| GSE13712_SHEAR | Up | 0.3147061956 |
| GSE13712_STATIC | Up | 0.1971992883 |
| GSE19018 | Down | -0.5288567008 |
| GSE19899_A1 | Down | -0.7826661521 |
| GSE19899_A2 | Down | -1.5704444614 |
| PubMed_21979375_A1 | Up | 0.0225869599 |
| PubMed_21979375_A2 | Down | -0.8425816537 |
| GSE35957 | Down | -1.3769006798 |
| GSE36640 | Down | -2.5232096001 |
| GSE54402 | Down | -0.0165483816 |
| GSE9593 | Down | -0.7880287305 |
| GSE43922 | Down | -0.3023435371 |
| GSE24585 | Down | -0.2348332092 |
| GSE37065 | Down | -0.5688744069 |
| GSE28863_A1 | Up | 0.2201526246 |
| GSE28863_A2 | Up | 0.4905060270 |
| GSE28863_A3 | Up | 0.2903622267 |
| GSE28863_A4 | Up | 0.2333283184 |
| GSE48662 | Down | -0.6713411598 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004852 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;Microarray;Other | Functional MTI | 19074876 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005131 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023401 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024348 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028693 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031312 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-935 | MIMAT0004978 | MIRT036694 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037165 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038062 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040957 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041386 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049504 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23475125 | Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors |
| 23475125 | Lamin A and the B-type lamins, lamin B1 and lamin B2, are translated as pre-proteins that are modified at a carboxyl terminal CAAX motif by farnesylation, proteolysis and carboxymethylation |
| 23475125 | Lamin B1 and lamin B2 play important roles in cell proliferation and organ development, but little is known about the role of farnesylation in their functions |
| 23475125 | Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A and a decrease in mature lamin B1 |
| 23475125 | Normally, lamins are concentrated at the nuclear envelope/lamina, but when farnesylation is inhibited, the peripheral localization of lamin B2 decreases as its nucleoplasmic levels increase |
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