HCSGD entry for ORAI1
1. General information
| Official gene symbol | ORAI1 |
|---|---|
| Entrez ID | 84876 |
| Gene full name | ORAI calcium release-activated calcium modulator 1 |
| Other gene symbols | CRACM1 ORAT1 TMEM142A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002115 | Store-operated calcium entry | IEA | biological_process |
| GO:0002376 | Immune system process | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0015279 | Store-operated calcium channel activity | IDA | molecular_function |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0051924 | Regulation of calcium ion transport | IMP | biological_process |
| GO:0051928 | Positive regulation of calcium ion transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0027846738 | 0.9501096501 | 0.1417765957 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6049664669 |
| GSE13712_SHEAR | Up | 0.0595467641 |
| GSE13712_STATIC | Up | 0.2535383836 |
| GSE19018 | Down | -0.0627332858 |
| GSE19899_A1 | Up | 0.5249180835 |
| GSE19899_A2 | Up | 2.1937443455 |
| PubMed_21979375_A1 | Up | 2.7317320729 |
| PubMed_21979375_A2 | Up | 2.0815121136 |
| GSE35957 | Down | -0.6151142647 |
| GSE36640 | Up | 0.0682084656 |
| GSE54402 | Up | 0.7081471596 |
| GSE9593 | Down | -0.2390431233 |
| GSE43922 | Up | 0.5161538359 |
| GSE24585 | Up | 0.6264501356 |
| GSE37065 | Down | -0.0757610746 |
| GSE28863_A1 | Down | -0.0326388569 |
| GSE28863_A2 | Down | -0.1057400537 |
| GSE28863_A3 | Up | 0.2992754243 |
| GSE28863_A4 | Up | 0.1487321395 |
| GSE48662 | Down | -0.1884023631 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26257076 | The importance of store-operated Ca(2+) entry (SOCE) and the role of its key molecular regulators, STIM1 and ORAI1, in the development of cancer are emerging |
| 26257076 | In addition, STIM1 and ORAI1 inhibited NF-kappaB signaling and remodeled the tumor microenvironment by reducing the formation of M2 phenotype macrophages, possibly creating an unfavorable tumor microenvironment and inhibiting cancer development |
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