HCSGD entry for MASTL
1. General information
| Official gene symbol | MASTL |
|---|---|
| Entrez ID | 84930 |
| Gene full name | microtubule associated serine/threonine kinase-like |
| Other gene symbols | GREATWALL GW GWL MAST-L RP11-85G18.2 THC2 hGWL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IMP | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | ISS | biological_process |
| GO:0007067 | Mitosis | IMP | biological_process |
| GO:0016301 | Kinase activity | IDA | molecular_function |
| GO:0032154 | Cleavage furrow | IDA | cellular_component |
| GO:0034048 | Negative regulation of protein phosphatase type 2A activity | IMP | biological_process |
| GO:0051721 | Protein phosphatase 2A binding | ISS | molecular_function |
| GO:0051726 | Regulation of cell cycle | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7857821587 | 0.0009072148 | 0.9999902473 | 0.0567192399 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5239812987 |
| GSE13712_SHEAR | Up | 0.6644763621 |
| GSE13712_STATIC | Up | 0.2787383006 |
| GSE19018 | Up | 0.1886476651 |
| GSE19899_A1 | Down | -1.3471051654 |
| GSE19899_A2 | Down | -2.3490514117 |
| PubMed_21979375_A1 | Down | -1.6709006481 |
| PubMed_21979375_A2 | Down | -2.5186094228 |
| GSE35957 | Down | -1.4991670869 |
| GSE36640 | Down | -2.0256883509 |
| GSE54402 | Down | -0.5668225512 |
| GSE9593 | Down | -0.9002029688 |
| GSE43922 | Down | -0.8745399268 |
| GSE24585 | Up | 0.1013390014 |
| GSE37065 | Up | 0.4775982703 |
| GSE28863_A1 | Down | -0.0075318185 |
| GSE28863_A2 | Up | 0.7418924150 |
| GSE28863_A3 | Down | -0.6460283096 |
| GSE28863_A4 | Up | 0.1418813221 |
| GSE48662 | Down | -0.6413934116 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT021059 | Reporter assay;Other | Functional MTI | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021059 | Reporter assay;Other | Non-Functional MTI | 20584899 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047078 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
