HCSGD entry for DGKZ
1. General information
| Official gene symbol | DGKZ |
|---|---|
| Entrez ID | 8525 |
| Gene full name | diacylglycerol kinase, zeta |
| Other gene symbols | DAGK5 DAGK6 DGK-ZETA hDGKzeta |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001727 | Lipid kinase activity | IDA | molecular_function |
| GO:0003951 | NAD+ kinase activity | IEA | molecular_function |
| GO:0004143 | Diacylglycerol kinase activity | IDA IEA | molecular_function |
| GO:0004857 | Enzyme inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IDA | molecular_function |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0016310 | Phosphorylation | IDA | biological_process |
| GO:0016477 | Cell migration | NAS | biological_process |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031571 | Mitotic G1 DNA damage checkpoint | IGI | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0045930 | Negative regulation of mitotic cell cycle | IGI | biological_process |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0046834 | Lipid phosphorylation | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1041970138 | 0.8825758064 | 0.6713456256 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0432154812 |
| GSE13712_SHEAR | Up | 0.0637925254 |
| GSE13712_STATIC | Up | 0.1265431226 |
| GSE19018 | Up | 0.1748923700 |
| GSE19899_A1 | Down | -0.0201534640 |
| GSE19899_A2 | Up | 0.2966411253 |
| PubMed_21979375_A1 | Up | 0.2912840244 |
| PubMed_21979375_A2 | Up | 0.8317192286 |
| GSE35957 | Down | -0.2014701593 |
| GSE36640 | Up | 0.1511004832 |
| GSE54402 | Up | 0.3680681830 |
| GSE9593 | Down | -0.1068272525 |
| GSE43922 | Up | 0.3606935935 |
| GSE24585 | Down | -0.2205363755 |
| GSE37065 | Down | -0.1349125676 |
| GSE28863_A1 | Down | -0.0634347685 |
| GSE28863_A2 | Up | 0.1069017738 |
| GSE28863_A3 | Up | 0.2321052419 |
| GSE28863_A4 | Up | 0.1693389410 |
| GSE48662 | Up | 0.0091176251 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029622 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043439 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
