HCSGD entry for DOCK7
1. General information
| Official gene symbol | DOCK7 |
|---|---|
| Entrez ID | 85440 |
| Gene full name | dedicator of cytokinesis 7 |
| Other gene symbols | ZIR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000226 | Microtubule cytoskeleton organization | IMP | biological_process |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007409 | Axonogenesis | IMP | biological_process |
| GO:0008180 | COP9 signalosome | IDA | cellular_component |
| GO:0030424 | Axon | TAS | cellular_component |
| GO:0030426 | Growth cone | TAS | cellular_component |
| GO:0031175 | Neuron projection development | IMP | biological_process |
| GO:0032863 | Activation of Rac GTPase activity | IDA | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IMP | biological_process |
| GO:0043005 | Neuron projection | TAS | cellular_component |
| GO:0043473 | Pigmentation | IEA | biological_process |
| GO:0045178 | Basal part of cell | TAS | cellular_component |
| GO:0045200 | Establishment of neuroblast polarity | IMP | biological_process |
| GO:0048365 | Rac GTPase binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9057064359 | 0.0226579309 | 0.9999902473 | 0.2897859086 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3927356519 |
| GSE13712_SHEAR | Up | 0.2627367464 |
| GSE13712_STATIC | Up | 0.0481394253 |
| GSE19018 | Down | -0.0729659564 |
| GSE19899_A1 | Down | -0.4684083905 |
| GSE19899_A2 | Down | -0.0866248287 |
| PubMed_21979375_A1 | Down | -1.1165810264 |
| PubMed_21979375_A2 | Down | -0.2600274768 |
| GSE35957 | Down | -0.0455548941 |
| GSE36640 | Up | 0.1924677999 |
| GSE54402 | Down | -0.1500793059 |
| GSE9593 | Up | 0.2555980841 |
| GSE43922 | Down | -0.3035444840 |
| GSE24585 | Down | -0.5953132835 |
| GSE37065 | Down | -0.1583452029 |
| GSE28863_A1 | Up | 0.1586646981 |
| GSE28863_A2 | Up | 0.6664875908 |
| GSE28863_A3 | Down | -0.8309630095 |
| GSE28863_A4 | Down | -0.4292161823 |
| GSE48662 | Up | 0.0719381273 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT006315 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 22158624 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005202 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-1307-3p | MIMAT0005951 | MIRT035812 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
