HCSGD entry for RUNX3
1. General information
| Official gene symbol | RUNX3 |
|---|---|
| Entrez ID | 864 |
| Gene full name | runt-related transcription factor 3 |
| Other gene symbols | AML2 CBFA3 PEBP2aC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0000790 | Nuclear chromatin | ISS | cellular_component |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISS | molecular_function |
| GO:0000981 | Sequence-specific DNA binding RNA polymerase II transcription factor activity | ISS | molecular_function |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA NAS | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007411 | Axon guidance | IEA | biological_process |
| GO:0031069 | Hair follicle morphogenesis | IEA | biological_process |
| GO:0032609 | Interferon-gamma production | IEA | biological_process |
| GO:0045786 | Negative regulation of cell cycle | ISS | biological_process |
| GO:0048469 | Cell maturation | IEA | biological_process |
| GO:0048935 | Peripheral nervous system neuron development | TAS | biological_process |
| GO:0050680 | Negative regulation of epithelial cell proliferation | ISS | biological_process |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3308881995 | 0.7415727822 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0813849733 |
| GSE13712_SHEAR | Up | 0.0561296946 |
| GSE13712_STATIC | Up | 0.0411110875 |
| GSE19018 | Up | 0.1435886984 |
| GSE19899_A1 | Up | 0.0133490609 |
| GSE19899_A2 | Up | 0.1776107701 |
| PubMed_21979375_A1 | Up | 0.0158516273 |
| PubMed_21979375_A2 | Down | -0.0692433774 |
| GSE35957 | Down | -1.1120343307 |
| GSE36640 | Up | 0.6216018405 |
| GSE54402 | Up | 0.2367280046 |
| GSE9593 | Down | -0.2361279368 |
| GSE43922 | Up | 0.1301251522 |
| GSE24585 | Down | -0.0551211567 |
| GSE37065 | Down | -0.0916017988 |
| GSE28863_A1 | Down | -0.1861881527 |
| GSE28863_A2 | Up | 0.1606029951 |
| GSE28863_A3 | Up | 0.4150110513 |
| GSE28863_A4 | Up | 0.0762803242 |
| GSE48662 | Down | -0.0470366108 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-532-5p | MIMAT0002888 | MIRT000038 | Flow//qRT-PCR | Functional MTI (Weak) | 19336521 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT003316 | qRT-PCR//Western blot | Functional MTI | 20176475 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT003316 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT007055 | Luciferase reporter assay//Western blot | Functional MTI | 22846564 |
| hsa-miR-301a-3p | MIMAT0000688 | MIRT007295 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23338485 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019365 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028012 | Sequencing | Functional MTI (Weak) | 20371350 |
Entries Per Page
Displaying Page of
- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-532-5p | MIMAT0002888 | 1 | hsa-miR-532-5p | {Western blot} | {downregulation by anti-miRNA oligonucleotide} | 19336521 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25540416 | EBNA3A colocalized with BATF-IRF4, ETS-IRF4, RUNX3, and other B-cell Transcription Factors (TFs) |
| 25540416 | EBNA3A coincidence with BATF-IRF4 or RUNX3 was associated with stronger EBNA3A ChIP-Seq signals |
| 25540416 | EBNA3A was at MYC, CDKN2A/B, CCND2, CXCL9/10, and BCL2, together with RUNX3, BATF, IRF4, and SPI1 |
Entries Per Page
Displaying Page of
