HCSGD entry for EIF3A
1. General information
| Official gene symbol | EIF3A |
|---|---|
| Entrez ID | 8661 |
| Gene full name | eukaryotic translation initiation factor 3, subunit A |
| Other gene symbols | EIF3 EIF3S10 P167 TIF32 eIF3-p170 eIF3-theta p180 p185 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001731 | Formation of translation preinitiation complex | IEA | biological_process |
| GO:0001732 | Formation of translation initiation complex | IDA IEA | biological_process |
| GO:0003743 | Translation initiation factor activity | IC IDA IEA | molecular_function |
| GO:0005198 | Structural molecule activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA NAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005852 | Eukaryotic translation initiation factor 3 complex | IDA IEA | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | IC TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016282 | Eukaryotic 43S preinitiation complex | IEA | cellular_component |
| GO:0033290 | Eukaryotic 48S preinitiation complex | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3943668288 | 0.4381344896 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1438177521 |
| GSE13712_SHEAR | Down | -0.1717856244 |
| GSE13712_STATIC | Down | -0.0956546950 |
| GSE19018 | Down | -0.3888063839 |
| GSE19899_A1 | Up | 0.0341765698 |
| GSE19899_A2 | Down | -0.1681592095 |
| PubMed_21979375_A1 | Down | -0.8182302409 |
| PubMed_21979375_A2 | Up | 0.1118993732 |
| GSE35957 | Down | -0.1018296328 |
| GSE36640 | Down | -0.2734434254 |
| GSE54402 | Up | 0.1236370851 |
| GSE9593 | Up | 0.0789013900 |
| GSE43922 | Down | -0.0007857834 |
| GSE24585 | Down | -0.0253810053 |
| GSE37065 | Down | -0.0158347875 |
| GSE28863_A1 | Up | 0.4974356923 |
| GSE28863_A2 | Up | 0.6606149834 |
| GSE28863_A3 | Up | 0.2475813390 |
| GSE28863_A4 | Up | 0.3813250969 |
| GSE48662 | Down | -0.0740575459 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020771 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031705 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040734 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040974 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042324 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051776 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
