HCSGD entry for EIF4G3
1. General information
| Official gene symbol | EIF4G3 |
|---|---|
| Entrez ID | 8672 |
| Gene full name | eukaryotic translation initiation factor 4 gamma, 3 |
| Other gene symbols | eIF-4G 3 eIF4G 3 eIF4GII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000339 | RNA cap binding | TAS | molecular_function |
| GO:0001934 | Positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003743 | Translation initiation factor activity | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006446 | Regulation of translational initiation | TAS | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008135 | Translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016281 | Eukaryotic translation initiation factor 4F complex | TAS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0045727 | Positive regulation of translation | IEA | biological_process |
| GO:0060903 | Positive regulation of meiosis I | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0740542533 | 0.9436441701 | 0.5781856550 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1642875185 |
| GSE13712_SHEAR | Down | -0.0342713253 |
| GSE13712_STATIC | Up | 0.0191330759 |
| GSE19018 | Up | 0.0965900590 |
| GSE19899_A1 | Up | 0.2188995844 |
| GSE19899_A2 | Up | 0.2796390611 |
| PubMed_21979375_A1 | Up | 0.3707825160 |
| PubMed_21979375_A2 | Up | 0.5042397862 |
| GSE35957 | Up | 0.2489138739 |
| GSE36640 | Up | 0.6503944053 |
| GSE54402 | Up | 0.3062669338 |
| GSE9593 | Up | 0.0144146636 |
| GSE43922 | Down | -0.0327276411 |
| GSE24585 | Up | 0.3239039445 |
| GSE37065 | Up | 0.0453252614 |
| GSE28863_A1 | Up | 0.2803220519 |
| GSE28863_A2 | Up | 0.4801820820 |
| GSE28863_A3 | Down | -0.1109566954 |
| GSE28863_A4 | Down | -0.3118983612 |
| GSE48662 | Up | 0.3185607403 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019790 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030431 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031458 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046895 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050935 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24497838 | Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development |
| 24497838 | Moreover, we demonstrate that miR-520c-3p directly targets translation initiation factor, eIF4GII mRNA and negatively regulates eIF4GII protein synthesis |
| 24497838 | Consequently, downregulation of eIF4GII by siRNA decreases translation, cell proliferation and ability to form colonies, as well as induces cellular senescence |
| 24497838 | In vitro and in vivo findings were further validated in patient samples; DLBCL primary cells demonstrated low miR-520c-3p levels with reciprocally up-regulated eIF4GII protein expression |
| 24497838 | Our results provide evidence that the tumor suppressor effect of miR-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII is a key effector of this anti-tumor activity |
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