HCSGD entry for CRADD

1. General information

Official gene symbolCRADD
Entrez ID8738
Gene full nameCASP2 and RIPK1 domain containing adaptor with death domain
Other gene symbolsMRT34 RAIDD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002020Protease bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIMPbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsICbiological_process
GO:0030674Protein binding, bridgingIPImolecular_function
GO:0042981Regulation of apoptotic processIEAbiological_process
GO:0070513Death domain bindingIPImolecular_function
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31559659210.27472034120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2110300187
GSE13712_SHEARUp0.0231858637
GSE13712_STATICUp0.0584325244
GSE19018Up0.0847892027
GSE19899_A1Down-0.3578737610
GSE19899_A2Up0.0665336174
PubMed_21979375_A1Up1.0637125735
PubMed_21979375_A2Down-0.3609398224
GSE35957Up0.0292908747
GSE36640Down-0.1677377478
GSE54402Up0.1844460570
GSE9593Down-0.1708945907
GSE43922Down-0.0300723251
GSE24585Down-0.4526405896
GSE37065Up0.1316875865
GSE28863_A1Up0.1933372845
GSE28863_A2Down-0.2201126480
GSE28863_A3Down-0.1971491425
GSE28863_A4Up0.0529576133
GSE48662Up0.2820190986

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029087MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.