HCSGD entry for TNFRSF10D
1. General information
| Official gene symbol | TNFRSF10D |
|---|---|
| Entrez ID | 8793 |
| Gene full name | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| Other gene symbols | CD264 DCR2 TRAIL-R4 TRAILR4 TRUNDD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0045569 | TRAIL binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0001835379 | 0.8260967402 | 0.0395975410 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2233448876 |
| GSE13712_SHEAR | Down | -0.5292815687 |
| GSE13712_STATIC | Down | -0.3961193933 |
| GSE19018 | Up | 0.8164072490 |
| GSE19899_A1 | Up | 1.7182599548 |
| GSE19899_A2 | Up | 2.9554893504 |
| PubMed_21979375_A1 | Up | 2.3388793951 |
| PubMed_21979375_A2 | Up | 1.3414086421 |
| GSE35957 | Up | 0.8260316160 |
| GSE36640 | Up | 1.6497366921 |
| GSE54402 | Up | 1.1956914690 |
| GSE9593 | Up | 0.8134253690 |
| GSE43922 | Up | 1.3304474698 |
| GSE24585 | Up | 0.4951557307 |
| GSE37065 | Up | 0.1476278306 |
| GSE28863_A1 | Down | -0.8973829925 |
| GSE28863_A2 | Down | -0.5606815904 |
| GSE28863_A3 | Down | -0.0301207702 |
| GSE28863_A4 | Up | 0.2574920930 |
| GSE48662 | Up | 0.5419881999 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018250 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30a-3p | MIMAT0000088 | MIRT049916 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24626611 | A variety of senescence-associated biomarkers including cathepsin D (CD), the eukaryotic translation elongation factors eEF1A1, eEF1B2, decoy receptor 2 and Dec1 were further validated in vivo or in vitro |
| 22258036 | Furthermore, DNA methylation levels of genes related to development of most or all tumor types, such as BRCA1, CCNA1, CDKN2A (p16), THBS1, TNFRSF10C and TNFRSF10D, were increased in BPA-exposed HMEC |
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