HCSGD entry for ACTN2

1. General information

Official gene symbolACTN2
Entrez ID88
Gene full nameactinin, alpha 2
Other gene symbolsCMD1AA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0003779Actin bindingIEAmolecular_function
GO:0005178Integrin bindingTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonNAScellular_component
GO:0005884Actin filamentTAScellular_component
GO:0005925Focal adhesionIMPcellular_component
GO:0006936Muscle contractionIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008092Cytoskeletal protein bindingIDAmolecular_function
GO:0008307Structural constituent of muscleTASmolecular_function
GO:0030018Z discIDA IEAcellular_component
GO:0030035Microspike assemblyIDAbiological_process
GO:0030049Muscle filament slidingTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030175FilopodiumIDAcellular_component
GO:0030274LIM domain bindingIEAmolecular_function
GO:0030375Thyroid hormone receptor coactivator activityIEAmolecular_function
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031143PseudopodiumTAScellular_component
GO:0031432Titin bindingIPImolecular_function
GO:0042391Regulation of membrane potentialIMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042981Regulation of apoptotic processNASbiological_process
GO:0043197Dendritic spineTAScellular_component
GO:0043267Negative regulation of potassium ion transportIMPbiological_process
GO:0043268Positive regulation of potassium ion transportIDAbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0046983Protein dimerization activityIDAmolecular_function
GO:0048041Focal adhesion assemblyIMPbiological_process
GO:0051015Actin filament bindingIEAmolecular_function
GO:0051289Protein homotetramerizationIDAbiological_process
GO:0051373FATZ bindingIDAmolecular_function
GO:0070080Titin Z domain bindingIPImolecular_function
GO:1901017Negative regulation of potassium ion transmembrane transporter activityIMPbiological_process
GO:1901018Positive regulation of potassium ion transmembrane transporter activityIDAbiological_process
GO:2000009Negative regulation of protein localization to cell surfaceIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45716541160.93151669770.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0199427152
GSE13712_SHEARUp0.0009994521
GSE13712_STATICUp0.1025408950
GSE19018Down-0.0076982495
GSE19899_A1Up0.0524898448
GSE19899_A2Up0.1277896247
PubMed_21979375_A1Up0.2231960764
PubMed_21979375_A2Up0.0756095998
GSE35957Down-0.0737802714
GSE36640Up0.0641642802
GSE54402Up0.0624467277
GSE9593Down-0.0143090154
GSE43922Up0.1096897872
GSE24585Down-0.0449913489
GSE37065Up0.6862104290
GSE28863_A1Down-0.0048446604
GSE28863_A2Up0.1582559009
GSE28863_A3Up0.1584895600
GSE28863_A4Down-0.0213091276
GSE48662Down-0.0547184719

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025892MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.