HCSGD entry for TSC22D1
1. General information
| Official gene symbol | TSC22D1 |
|---|---|
| Entrez ID | 8848 |
| Gene full name | TSC22 domain family, member 1 |
| Other gene symbols | Ptg-2 TGFB1I4 TSC22 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2020229513 | 0.3673603473 | 0.8675878773 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2138560535 |
| GSE13712_SHEAR | Up | 0.0579457739 |
| GSE13712_STATIC | Up | 0.1520496432 |
| GSE19018 | Down | -0.4225905798 |
| GSE19899_A1 | Up | 0.2138307356 |
| GSE19899_A2 | Up | 0.0075802037 |
| PubMed_21979375_A1 | Down | -0.3597343055 |
| PubMed_21979375_A2 | Up | 0.0094677386 |
| GSE35957 | Up | 0.5855916180 |
| GSE36640 | Up | 0.5344657929 |
| GSE54402 | Up | 0.1417150726 |
| GSE9593 | Up | 0.0270970646 |
| GSE43922 | Down | -0.6637248391 |
| GSE24585 | Up | 0.0520021028 |
| GSE37065 | Down | -0.0947310202 |
| GSE28863_A1 | Up | 0.2482997499 |
| GSE28863_A2 | Up | 0.1343936418 |
| GSE28863_A3 | Down | -0.5005436204 |
| GSE28863_A4 | Up | 0.2779934355 |
| GSE48662 | Up | 0.3399053589 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-100-5p | MIMAT0000098 | MIRT048416 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21448135 | Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence |
| 21448135 | Gene-expression profiling revealed a >100-fold increase in the levels of the transcription factor and putative tumour suppressor gene TGFbeta-stimulated clone 22 (TSC22D1) in BRAF(E600)-induced senescence, in both human fibroblasts and melanocytes |
| 21448135 | Only the short TSC22D1 transcript was upregulated, whereas the abundance of the large protein variant was suppressed by proteasomal degradation |
| 21448135 | This was accompanied by the suppression of several inflammatory factors and p15(INK4B), with TSC22D1 acting as a critical effector of C/EBPbeta |
| 21448135 | Our results demonstrate that the differential regulation of antagonistic TSC22D1 variants is required for the establishment of OIS and suggest distinct contributions of TSC22 family members to the progression of BRAF(E600)-driven neoplasia |
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