HCSGD entry for NAT1
1. General information
| Official gene symbol | NAT1 |
|---|---|
| Entrez ID | 9 |
| Gene full name | N-acetyltransferase 1 (arylamine N-acetyltransferase) |
| Other gene symbols | AAC1 MNAT NAT-1 NATI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004060 | Arylamine N-acetyltransferase activity | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0016407 | Acetyltransferase activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8481844117 | 0.0110965199 | 0.9999902473 | 0.2083282965 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1684125099 |
| GSE13712_SHEAR | Up | 0.0175495041 |
| GSE13712_STATIC | Up | 0.3787019546 |
| GSE19018 | Down | -0.2247073500 |
| GSE19899_A1 | Down | -1.1244194083 |
| GSE19899_A2 | Down | -1.2908973105 |
| PubMed_21979375_A1 | Down | -1.7334757522 |
| PubMed_21979375_A2 | Down | -1.7950049800 |
| GSE35957 | Up | 0.2754600137 |
| GSE36640 | Up | 0.4193200221 |
| GSE54402 | Down | -0.8059174999 |
| GSE9593 | Up | 0.0669969488 |
| GSE43922 | Down | -0.8360706517 |
| GSE24585 | Up | 0.1833387459 |
| GSE37065 | Up | 0.1259903526 |
| GSE28863_A1 | Down | -0.0893314577 |
| GSE28863_A2 | Down | -0.0305165546 |
| GSE28863_A3 | Down | -0.2021735121 |
| GSE28863_A4 | Down | -0.0693035834 |
| GSE48662 | Down | -0.4802680231 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030309 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050208 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22686306 | Variable NAT1 enzyme activity in long-term cultured human HaCaT keratinocytes |
| 22686306 | Furthermore, the activities of the xenobiotic metabolizing phase II enzyme N-acetyltransferase 1 (NAT1) were higher in the late passages compared to the early passages |
| 22686306 | Furthermore, the activities of the xenobiotic metabolizing phase II enzyme N-acetyltransferase 1 (NAT1) were higher in the late passages compared to the early passages |
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