HCSGD entry for CCNG1
1. General information
| Official gene symbol | CCNG1 |
|---|---|
| Entrez ID | 900 |
| Gene full name | cyclin G1 |
| Other gene symbols | CCNG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006949 | Syncytium formation | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007095 | Mitotic G2 DNA damage checkpoint | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0010243 | Response to organonitrogen compound | IEA | biological_process |
| GO:0016049 | Cell growth | IEA | biological_process |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4132167357 | 0.2082814559 | 0.9999902473 | 0.8832247785 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1313676178 |
| GSE13712_SHEAR | Down | -0.2994523926 |
| GSE13712_STATIC | Down | -0.1104598809 |
| GSE19018 | Up | 0.9659024322 |
| GSE19899_A1 | Up | 0.1238901167 |
| GSE19899_A2 | Up | 0.1999372107 |
| PubMed_21979375_A1 | Down | -0.4121978528 |
| PubMed_21979375_A2 | Up | 0.0933644632 |
| GSE35957 | Down | -0.0040299570 |
| GSE36640 | Up | 0.0811297016 |
| GSE54402 | Down | -0.3449667453 |
| GSE9593 | Up | 0.2981909837 |
| GSE43922 | Down | -0.0575800104 |
| GSE24585 | Up | 0.2031454144 |
| GSE37065 | Down | -0.0151380422 |
| GSE28863_A1 | Down | -0.0635696221 |
| GSE28863_A2 | Down | -0.1265861694 |
| GSE28863_A3 | Down | -0.9033822578 |
| GSE28863_A4 | Down | -0.1236376903 |
| GSE48662 | Down | -0.2063951318 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003006 | Reporter assay | Functional MTI | 17616664 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003006 | Western blot | Functional MTI | 19584283 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003006 | qRT-PCR | Functional MTI (Weak) | 23126531 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003006 | Reporter assay;Western blot | Functional MTI | 18692484 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT006782 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025126 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031062 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048101 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048390 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT050379 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050754 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051412 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051584 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051874 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052358 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052643 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12668979 | Cyclin G1 is a transcriptional target of the tumor suppressor p53, and its expression is increased after DNA damage |
| 12668979 | Recent data show that cyclin G1 can regulate the levels of p53 by a mechanism that involves dephosphorylation of Mdm2 by protein phosphatase 2A |
| 12668979 | To understand the biologic role of cyclin G1, we have generated cyclin G1-deficient mice |
| 12668979 | Taken with recent published data, our results suggest that cyclin G1, together with Mdm2, constitute a part of a negative feedback system that attenuates the activity of p53 |
| 12668979 | In conclusion, our data suggest that the decreased tumor susceptibility after loss of cyclin G1 function is caused by the increased tumor suppressor action of p53 |
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