HCSGD entry for SOCS3

1. General information

Official gene symbolSOCS3
Entrez ID9021
Gene full namesuppressor of cytokine signaling 3
Other gene symbolsATOD4 CIS3 Cish3 SOCS-3 SSI-3 SSI3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004860Protein kinase inhibitor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0006469Negative regulation of protein kinase activityTASbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0016567Protein ubiquitinationIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0040008Regulation of growthIEAbiological_process
GO:0042326Negative regulation of phosphorylationTASbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043086Negative regulation of catalytic activityTASbiological_process
GO:0045597Positive regulation of cell differentiationIEAbiological_process
GO:0045859Regulation of protein kinase activityTASbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIEAbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0060670Branching involved in labyrinthine layer morphogenesisIEAbiological_process
GO:0060674Placenta blood vessel developmentIEAbiological_process
GO:0060707Trophoblast giant cell differentiationIEAbiological_process
GO:0060708Spongiotrophoblast differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01394078490.92822951640.29370439651.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1995913685
GSE13712_SHEARUp0.2673348714
GSE13712_STATICUp0.4253913084
GSE19018Down-0.0134998815
GSE19899_A1Up0.2898285800
GSE19899_A2Up0.6956136905
PubMed_21979375_A1Up0.8484396150
PubMed_21979375_A2Up0.4297544089
GSE35957Down-0.6549350954
GSE36640Down-0.6446054924
GSE54402Up0.6354937473
GSE9593Down-0.2173906679
GSE43922Up0.5132745014
GSE24585Up0.2926776818
GSE37065Down-0.2409219251
GSE28863_A1Up0.6735300234
GSE28863_A2Up0.4535519776
GSE28863_A3Up0.4633631991
GSE28863_A4Up0.1352454482
GSE48662Up0.0325722107

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-203aMIMAT0000264MIRT005062Immunohistochemistry//In situ hybridization//Microarray//Western blotFunctional MTI17622355
hsa-miR-203aMIMAT0000264MIRT005062Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22207897
hsa-miR-30c-5pMIMAT0000244MIRT007129qRT-PCRFunctional MTI (Weak)23418453
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-203aMIMAT00002641hsa-miR-20317622355
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24551275Cell cycle regulatory proteins Cyclin D1 and SOCS3 were significantly enhanced in AEC within the remodelled fibrotic areas of IPF lungs but expression was negligible in myofibroblasts
22473749Immunoprecipitation analyses revealed that SOCS3 bound p53 and subsequently increased the expression of p53 and its target genes, contributing to IL-22-mediated HSC senescence
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