HCSGD entry for KNSTRN
1. General information
| Official gene symbol | KNSTRN |
|---|---|
| Entrez ID | 90417 |
| Gene full name | kinetochore-localized astrin/SPAG5 binding protein |
| Other gene symbols | C15orf23 SKAP TRAF4AF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000070 | Mitotic sister chromatid segregation | IMP | biological_process |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007051 | Spindle organization | IMP | biological_process |
| GO:0007059 | Chromosome segregation | IMP | biological_process |
| GO:0035371 | Microtubule plus-end | IDA | cellular_component |
| GO:0051988 | Regulation of attachment of spindle microtubules to kinetochore | IMP | biological_process |
| GO:0072686 | Mitotic spindle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8753891228 | 0.0047494282 | 0.9999902473 | 0.1398318792 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4009790672 |
| GSE13712_SHEAR | Up | 0.1545167886 |
| GSE13712_STATIC | Down | -0.3329465132 |
| GSE19018 | Down | -0.0457826889 |
| GSE19899_A1 | Down | -0.3192147647 |
| GSE19899_A2 | Down | -1.0625858000 |
| PubMed_21979375_A1 | Down | -0.9549322390 |
| PubMed_21979375_A2 | Down | -1.5045336998 |
| GSE35957 | Down | -0.9402909516 |
| GSE36640 | Down | -2.0491869420 |
| GSE54402 | Up | 0.0652929792 |
| GSE9593 | Up | 0.4364506382 |
| GSE43922 | Down | -0.2084350861 |
| GSE24585 | Down | -0.2331309475 |
| GSE37065 | Down | -0.3071954236 |
| GSE28863_A1 | Down | -0.3366324660 |
| GSE28863_A2 | Up | 0.5335261384 |
| GSE28863_A3 | Up | 0.0503071924 |
| GSE28863_A4 | Up | 0.3873448553 |
| GSE48662 | Down | -0.9010787193 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-222-3p | MIMAT0000279 | MIRT046798 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
