HCSGD entry for PAPSS1
1. General information
| Official gene symbol | PAPSS1 |
|---|---|
| Entrez ID | 9061 |
| Gene full name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| Other gene symbols | ATPSK1 PAPSS SK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000103 | Sulfate assimilation | IEA | biological_process |
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0004020 | Adenylylsulfate kinase activity | IEA | molecular_function |
| GO:0004781 | Sulfate adenylyltransferase (ATP) activity | ISS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0016779 | Nucleotidyltransferase activity | ISS | molecular_function |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | TAS | biological_process |
| GO:0050428 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8917092360 | 0.0945505452 | 0.9999902473 | 0.5859803437 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2052852136 |
| GSE13712_SHEAR | Down | -0.3063480280 |
| GSE13712_STATIC | Down | -0.2533634080 |
| GSE19018 | Down | -0.2554660365 |
| GSE19899_A1 | Up | 0.2046585421 |
| GSE19899_A2 | Up | 0.0164620159 |
| PubMed_21979375_A1 | Down | -0.5395835184 |
| PubMed_21979375_A2 | Up | 0.0801636748 |
| GSE35957 | Down | -0.1164533247 |
| GSE36640 | Up | 0.0445112596 |
| GSE54402 | Up | 0.1960105729 |
| GSE9593 | Down | -0.1601300326 |
| GSE43922 | Up | 0.0129827920 |
| GSE24585 | Up | 0.1723753352 |
| GSE37065 | Down | -0.2880718837 |
| GSE28863_A1 | Down | -0.2167339672 |
| GSE28863_A2 | Down | -0.0440015212 |
| GSE28863_A3 | Down | -0.7510767359 |
| GSE28863_A4 | Down | -0.0805950469 |
| GSE48662 | Down | -0.5911885445 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine-5'-Diphosphate-2',3'-Vanadate | DB02661 | EXPT00592 |
| Adenosine-5'-Phosphosulfate | DB03708 | EXPT00441 |
| Glycerol | DB04077 | EXPT01027 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032474 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048587 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24478790 | From the genome wide association analysis in 4,289 LLFS participants, we identified a novel intergenic SNP rs7680468 located near PAPSS1 and DKK2 on 4q25 (p = 4 |
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