HCSGD entry for ASH2L
1. General information
| Official gene symbol | ASH2L |
|---|---|
| Entrez ID | 9070 |
| Gene full name | ash2 (absent, small, or homeotic)-like (Drosophila) |
| Other gene symbols | ASH2 ASH2L1 ASH2L2 Bre2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IC | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | NAS | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0030097 | Hemopoiesis | NAS | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA IPI | cellular_component |
| GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | IDA | molecular_function |
| GO:0043627 | Response to estrogen | IDA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9569675050 | 0.0272161658 | 0.9999902473 | 0.3144582018 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0751961397 |
| GSE13712_SHEAR | Down | -0.7543086604 |
| GSE13712_STATIC | Down | -0.4892500862 |
| GSE19018 | Up | 0.0379759677 |
| GSE19899_A1 | Down | -0.3191616406 |
| GSE19899_A2 | Down | -0.2426044059 |
| PubMed_21979375_A1 | Down | -1.1403236322 |
| PubMed_21979375_A2 | Down | -0.2119616221 |
| GSE35957 | Down | -0.5159991678 |
| GSE36640 | Down | -0.6870489597 |
| GSE54402 | Down | -0.0345774605 |
| GSE9593 | Down | -0.1231192338 |
| GSE43922 | Down | -0.3411197174 |
| GSE24585 | Up | 0.6832284980 |
| GSE37065 | Up | 0.0616442927 |
| GSE28863_A1 | Up | 0.0293057922 |
| GSE28863_A2 | Up | 0.3013975074 |
| GSE28863_A3 | Down | -0.3659746367 |
| GSE28863_A4 | Down | -0.2031799021 |
| GSE48662 | Down | -0.2429440317 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001383 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036952 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-2-3p | MIMAT0004603 | MIRT038629 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
