HCSGD entry for DNAJA3
1. General information
| Official gene symbol | DNAJA3 |
|---|---|
| Entrez ID | 9093 |
| Gene full name | DnaJ (Hsp40) homolog, subfamily A, member 3 |
| Other gene symbols | HCA57 TID1 hTID-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0005083 | Small GTPase regulator activity | IEA | molecular_function |
| GO:0005133 | Interferon-gamma receptor binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA IMP | cellular_component |
| GO:0005884 | Actin filament | IDA | cellular_component |
| GO:0006264 | Mitochondrial DNA replication | IEA | biological_process |
| GO:0006457 | Protein folding | IDA IEA | biological_process |
| GO:0006469 | Negative regulation of protein kinase activity | IDA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0006924 | Activation-induced cell death of T cells | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007528 | Neuromuscular junction development | IDA | biological_process |
| GO:0007569 | Cell aging | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0008385 | IkappaB kinase complex | IDA | cellular_component |
| GO:0009408 | Response to heat | IEA | biological_process |
| GO:0009790 | Embryo development | IEA | biological_process |
| GO:0019897 | Extrinsic component of plasma membrane | ISS | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030544 | Hsp70 protein binding | IEA | molecular_function |
| GO:0030971 | Receptor tyrosine kinase binding | IEA | molecular_function |
| GO:0031072 | Heat shock protein binding | IEA | molecular_function |
| GO:0031398 | Positive regulation of protein ubiquitination | IDA | biological_process |
| GO:0031594 | Neuromuscular junction | ISS | cellular_component |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0033077 | T cell differentiation in thymus | IEA | biological_process |
| GO:0033256 | I-kappaB/NF-kappaB complex | IDA | cellular_component |
| GO:0034341 | Response to interferon-gamma | IDA | biological_process |
| GO:0042102 | Positive regulation of T cell proliferation | IEA | biological_process |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043124 | Negative regulation of I-kappaB kinase/NF-kappaB signaling | IDA | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0045211 | Postsynaptic membrane | ISS | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050821 | Protein stabilization | IDA | biological_process |
| GO:0051059 | NF-kappaB binding | IPI | molecular_function |
| GO:0051082 | Unfolded protein binding | IEA | molecular_function |
| GO:0060336 | Negative regulation of interferon-gamma-mediated signaling pathway | IDA | biological_process |
| GO:0071340 | Skeletal muscle acetylcholine-gated channel clustering | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0315405456 | 0.8103917480 | 0.4107761999 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5785888162 |
| GSE13712_SHEAR | Down | -0.0672146315 |
| GSE13712_STATIC | Up | 0.2452782728 |
| GSE19018 | Down | -0.6032206273 |
| GSE19899_A1 | Up | 0.2989957970 |
| GSE19899_A2 | Up | 0.6244387099 |
| PubMed_21979375_A1 | Up | 2.3969203555 |
| PubMed_21979375_A2 | Up | 0.6544687450 |
| GSE35957 | Down | -0.2869991543 |
| GSE36640 | Up | 0.1783259652 |
| GSE54402 | Up | 0.3027243797 |
| GSE9593 | Down | -0.0790119875 |
| GSE43922 | Up | 0.2725828186 |
| GSE24585 | Down | -0.2908184648 |
| GSE37065 | Down | -0.1422500920 |
| GSE28863_A1 | Up | 0.2771759770 |
| GSE28863_A2 | Up | 0.3025926473 |
| GSE28863_A3 | Up | 0.0621283553 |
| GSE28863_A4 | Down | -0.0785850943 |
| GSE48662 | Down | -0.1761209975 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029308 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-550a-3p | MIMAT0003257 | MIRT040500 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041303 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042039 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043778 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045410 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048688 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049135 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15572682 | Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival |
| 15572682 | They include mouse Tid1, a homologue of the Drosophila tumor suppressor gene l(2)tid, recently implicated in modulation of apoptosis as well as gamma interferon and NF-kappaB signaling |
| 15572682 | Expression of Tid1 is upregulated upon cellular senescence in rat and mouse embryo fibroblasts and premature senescence of REF52 cells triggered by activated ras |
| 15572682 | In accordance with this, spontaneous immortalization of rat embryo fibroblasts is suppressed upon ectopic expression of Tid1 |
| 15572682 | Modulation of endogenous Tid1 activity by GSE-Tid1 or Tid1-specific RNA interference alleviates the suppression of tumor necrosis factor alpha-induced NF-kappaB activity by Tid1 |
| 15572682 | We therefore propose that Tid1 contributes to senescence by acting as a repressor of NF-kappaB signaling |
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