HCSGD entry for USP2
1. General information
| Official gene symbol | USP2 |
|---|---|
| Entrez ID | 9099 |
| Gene full name | ubiquitin specific peptidase 2 |
| Other gene symbols | UBP41 USP9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0004197 | Cysteine-type endopeptidase activity | TAS | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005813 | Centrosome | IEA | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007517 | Muscle organ development | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0016579 | Protein deubiquitination | IDA | biological_process |
| GO:0030332 | Cyclin binding | IPI | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0048642 | Negative regulation of skeletal muscle tissue development | IEA | biological_process |
| GO:0048643 | Positive regulation of skeletal muscle tissue development | IEA | biological_process |
| GO:0050821 | Protein stabilization | IDA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8749190114 | 0.5930859048 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0520876996 |
| GSE13712_SHEAR | Down | -0.1585571184 |
| GSE13712_STATIC | Down | -0.0381521928 |
| GSE19018 | Up | 0.0432557397 |
| GSE19899_A1 | Up | 0.0280075460 |
| GSE19899_A2 | Up | 0.2092802611 |
| PubMed_21979375_A1 | Up | 0.2618507516 |
| PubMed_21979375_A2 | Down | -0.1699003560 |
| GSE35957 | Down | -0.0098226810 |
| GSE36640 | Up | 0.0370587612 |
| GSE54402 | Down | -0.1034202140 |
| GSE9593 | Up | 0.0427187028 |
| GSE43922 | Down | -0.1185886575 |
| GSE24585 | Down | -0.0924606576 |
| GSE37065 | Down | -0.0098503540 |
| GSE28863_A1 | Down | -0.0817290792 |
| GSE28863_A2 | Up | 0.1101089155 |
| GSE28863_A3 | Up | 0.1443177926 |
| GSE28863_A4 | Up | 0.0648812132 |
| GSE48662 | Down | -0.0684484866 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-5p | MIMAT0004949 | MIRT037275 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051401 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
