HCSGD entry for USP8
1. General information
| Official gene symbol | USP8 |
|---|---|
| Entrez ID | 9101 |
| Gene full name | ubiquitin specific peptidase 8 |
| Other gene symbols | HumORF8 UBPY |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000281 | Mitotic cytokinesis | IMP | biological_process |
| GO:0001669 | Acrosomal vesicle | IEA | cellular_component |
| GO:0004197 | Cysteine-type endopeptidase activity | TAS | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007032 | Endosome organization | IMP | biological_process |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0010008 | Endosome membrane | IEA | cellular_component |
| GO:0016579 | Protein deubiquitination | IEA IMP | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0019897 | Extrinsic component of plasma membrane | IDA | cellular_component |
| GO:0030496 | Midbody | IDA IEA | cellular_component |
| GO:0070536 | Protein K63-linked deubiquitination | IDA | biological_process |
| GO:0071108 | Protein K48-linked deubiquitination | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5564112116 | 0.4647161696 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0767024238 |
| GSE13712_SHEAR | Down | -0.1293498429 |
| GSE13712_STATIC | Up | 0.1259510212 |
| GSE19018 | Down | -0.2491992648 |
| GSE19899_A1 | Up | 0.1125092520 |
| GSE19899_A2 | Up | 0.1189490393 |
| PubMed_21979375_A1 | Up | 0.5193600046 |
| PubMed_21979375_A2 | Up | 0.7780480285 |
| GSE35957 | Down | -0.1573541499 |
| GSE36640 | Down | -0.1828406916 |
| GSE54402 | Up | 0.1097867991 |
| GSE9593 | Down | -0.1128587777 |
| GSE43922 | Up | 0.0812288086 |
| GSE24585 | Down | -0.0360046550 |
| GSE37065 | Up | 0.2065167502 |
| GSE28863_A1 | Up | 0.0771884003 |
| GSE28863_A2 | Down | -0.2289000048 |
| GSE28863_A3 | Down | -0.2861184706 |
| GSE28863_A4 | Up | 0.0683781687 |
| GSE48662 | Down | -0.5404094724 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-374a-5p | MIMAT0000727 | MIRT044017 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046085 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047051 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051165 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
