HCSGD entry for ARHGEF1
1. General information
| Official gene symbol | ARHGEF1 |
|---|---|
| Entrez ID | 9138 |
| Gene full name | Rho guanine nucleotide exchange factor (GEF) 1 |
| Other gene symbols | GEF1 LBCL2 LSC P115-RHOGEF SUB1.5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007266 | Rho protein signal transduction | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | TAS | biological_process |
| GO:0032319 | Regulation of Rho GTPase activity | TAS | biological_process |
| GO:0038032 | Termination of G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0043087 | Regulation of GTPase activity | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0050770 | Regulation of axonogenesis | TAS | biological_process |
| GO:0050771 | Negative regulation of axonogenesis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4714187645 | 0.7186481175 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0514096044 |
| GSE13712_SHEAR | Up | 0.3391421303 |
| GSE13712_STATIC | Up | 0.4062566609 |
| GSE19018 | Up | 0.0950399360 |
| GSE19899_A1 | Down | -0.0128799017 |
| GSE19899_A2 | Down | -0.0442748199 |
| PubMed_21979375_A1 | Down | -0.5589257913 |
| PubMed_21979375_A2 | Up | 0.2862123661 |
| GSE35957 | Up | 0.1941074184 |
| GSE36640 | Up | 0.0856326781 |
| GSE54402 | Down | -0.0265290098 |
| GSE9593 | Down | -0.3390037062 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0253337512 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002695 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002695 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018227 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043573 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050115 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25993799 | The ability of LSC proliferation treated by various concentration of ASP(20-80 mg |
| 25993799 | The proliferation of LSC was exhibited significantly concentration-dependent inhibited after exposure to various concentration of ASP |
| 23296652 | The characteristic features of senescent cells such as their "flattened" appearance, enlarged nuclei and low saturation density at the plateau phase of cell growth, can be conveniently measured by image-assisted cytometry such as provided by a laser scanning cytometer (LSC) |
| 23027005 | Laser scanning cytometer (LSC) is the microscope-based cytofluorometer that offers a plethora of unique analytical capabilities, not provided by flow cytometry (FCM) |
| 23027005 | This review describes attributes of LSC and covers its numerous applications derived from plentitude of the parameters that can be measured |
| 23027005 | Advantages and limitations of LSC are discussed and compared with FCM |
| 21624810 | Together, these results reveal an important functional interplay between MLL/Hox and Bmi1 in regulating cellular senescence for LSC development, suggesting that a synergistic targeting of both molecules is required to eradicate a broader spectrum of LSCs |
| 20939035 | The imaging analytical capabilities of laser scanning cytometer (LSC) have been used to assess morphological features considered to be typical of the senescent phenotype |
| 20939035 | The saturation cell density at plateau phase of growth recorded by LSC was found to be dramatically decreased in cultures of senescent cells, thereby also serving as an additional marker |
| 20939035 | The data show that morphometric analysis of cellular attributes by LSC offers an attractive tool to detect cell senescence and measure its degree particularly in assessing effects of the factors that enhance or attenuate this process |
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