HCSGD entry for HGS
1. General information
| Official gene symbol | HGS |
|---|---|
| Entrez ID | 9146 |
| Gene full name | hepatocyte growth factor-regulated tyrosine kinase substrate |
| Other gene symbols | HRS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0008333 | Endosome to lysosome transport | IEA | biological_process |
| GO:0009966 | Regulation of signal transduction | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016197 | Endosomal transport | IEA NAS TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030141 | Secretory granule | IEA | cellular_component |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0032585 | Multivesicular body membrane | IEA | cellular_component |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0042176 | Regulation of protein catabolic process | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046426 | Negative regulation of JAK-STAT cascade | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0927786824 | 0.9673092588 | 0.6390117416 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0995900857 |
| GSE13712_SHEAR | Up | 0.3726187835 |
| GSE13712_STATIC | Up | 0.5630867480 |
| GSE19018 | Up | 0.1539231301 |
| GSE19899_A1 | Down | -0.1554318678 |
| GSE19899_A2 | Up | 0.1300091933 |
| PubMed_21979375_A1 | Up | 0.5274485973 |
| PubMed_21979375_A2 | Up | 0.9334372559 |
| GSE35957 | Down | -0.3709628620 |
| GSE36640 | Down | -0.0057924006 |
| GSE54402 | Up | 0.2187818406 |
| GSE9593 | Up | 0.0695539396 |
| GSE43922 | Up | 0.0241707596 |
| GSE24585 | Up | 0.1382067965 |
| GSE37065 | Down | -0.0333486039 |
| GSE28863_A1 | Up | 0.1091413650 |
| GSE28863_A2 | Up | 0.3173828920 |
| GSE28863_A3 | Up | 0.2914179953 |
| GSE28863_A4 | Up | 0.0514192032 |
| GSE48662 | Up | 0.0158103984 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Citric Acid | DB04272 | EXPT00922 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-5p | MIMAT0000690 | MIRT004900 | Luciferase reporter assay//Western blot | Functional MTI | 18977327 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037009 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042598 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052221 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-296-5p | MIMAT0000690 | 1 | hsa-miR-296-5p | 18977327 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
