HCSGD entry for MTG1
1. General information
| Official gene symbol | MTG1 |
|---|---|
| Entrez ID | 92170 |
| Gene full name | mitochondrial ribosome-associated GTPase 1 |
| Other gene symbols | GTP GTPBP7 RP11-108K14.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IBA IDA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0005761 | Mitochondrial ribosome | IDA | cellular_component |
| GO:0006184 | GTP catabolic process | IDA | biological_process |
| GO:0042254 | Ribosome biogenesis | IBA | biological_process |
| GO:0044065 | Regulation of respiratory system process | IMP | biological_process |
| GO:0070129 | Regulation of mitochondrial translation | IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7576188975 | 0.1939953763 | 0.9999902473 | 0.8534434732 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1075751826 |
| GSE13712_SHEAR | Down | -0.1203576453 |
| GSE13712_STATIC | Down | -0.0879635155 |
| GSE19018 | Down | -0.3206641392 |
| GSE19899_A1 | Down | -0.1409438280 |
| GSE19899_A2 | Down | -0.1361130624 |
| PubMed_21979375_A1 | Up | 1.2445206994 |
| PubMed_21979375_A2 | Up | 0.1486545188 |
| GSE35957 | Down | -0.5431923930 |
| GSE36640 | Down | -0.1619879889 |
| GSE54402 | Up | 0.2421515760 |
| GSE9593 | Down | -0.6921563936 |
| GSE43922 | Up | 0.0681674289 |
| GSE24585 | Down | -0.3950090190 |
| GSE37065 | Down | -0.0331908866 |
| GSE28863_A1 | Up | 0.0085112117 |
| GSE28863_A2 | Down | -0.0369912327 |
| GSE28863_A3 | Up | 0.0217213501 |
| GSE28863_A4 | Up | 0.0700857424 |
| GSE48662 | Down | -0.2458699040 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040253 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041976 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25286227 | However, Rho proteins are inherently inefficient at fulfilling this cycle and require the actions of regulatory proteins that enhance GTP binding (RhoGEFs), stimulate GTPase activity (RhoGAPs), and sequester inactive Rho proteins in the cytosol (RhoGDIs) |
| 23160023 | BACKGROUND: The small GTPase Ran, Ras-related nuclear protein, plays important roles in multiple fundamental cellular functions such as nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation, by binding to either GTP or GDP as a molecular switch |
| 22897574 | In addition, the expressions of moesin and rho GTP dissociation inhibitor, additional age-related candidate biomarkers, were decreased by PON1 knock-down in HDMECs |
| 9447988 | Reverse transcriptase inhibitors such as dideoxy GTP efficiently inhibit P |
| 1319530 | Adenylate cyclase responses to prostaglandin E1 (PGE1, 1 microM), guanosine triphosphate (GTP, 0 |
Entries Per Page
Displaying Page of
