HCSGD entry for NOG

1. General information

Official gene symbolNOG
Entrez ID9241
Gene full namenoggin
Other gene symbolsSYM1 SYNS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001501Skeletal system developmentTASbiological_process
GO:0001649Osteoblast differentiationISSbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001706Endoderm formationIEAbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0001839Neural plate morphogenesisIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0007399Nervous system developmentTASbiological_process
GO:0008045Motor neuron axon guidanceIEAbiological_process
GO:0009953Dorsal/ventral pattern formationIDAbiological_process
GO:0019955Cytokine bindingIPImolecular_function
GO:0021510Spinal cord developmentIEAbiological_process
GO:0021533Cell differentiation in hindbrainIMPbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIDA ISSbiological_process
GO:0035019Somatic stem cell maintenanceIMPbiological_process
GO:0042060Wound healingISSbiological_process
GO:0042474Middle ear morphogenesisIMPbiological_process
GO:0042733Embryonic digit morphogenesisIMPbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0045668Negative regulation of osteoblast differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048318Axial mesoderm developmentIEAbiological_process
GO:0048570Notochord morphogenesisIEAbiological_process
GO:0048706Embryonic skeletal system developmentIMPbiological_process
GO:0048712Negative regulation of astrocyte differentiationISSbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0060044Negative regulation of cardiac muscle cell proliferationISSbiological_process
GO:0060173Limb developmentIMPbiological_process
GO:0060272Embryonic skeletal joint morphogenesisIMPbiological_process
GO:0060302Negative regulation of cytokine activityIPIbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0060394Negative regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060425Lung morphogenesisIEAbiological_process
GO:0060513Prostatic bud formationIEAbiological_process
GO:0060676Ureteric bud formationIEAbiological_process
GO:0060825Fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationIMPbiological_process
GO:0061037Negative regulation of cartilage developmentIEAbiological_process
GO:0061053Somite developmentIEAbiological_process
GO:0071773Cellular response to BMP stimulusIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisISSbiological_process
GO:0090193Positive regulation of glomerulus developmentISSbiological_process
GO:2000313Regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationIMPbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01087169560.01120265570.26362348070.2091769504

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0728216649
GSE13712_SHEARUp0.9312922771
GSE13712_STATICUp0.5921816018
GSE19018Up0.4285018679
GSE19899_A1Down-0.9089958476
GSE19899_A2Up2.3342071801
PubMed_21979375_A1Up1.4186458165
PubMed_21979375_A2Up1.0395256120
GSE35957Up1.5710665343
GSE36640Up0.8186200463
GSE54402Down-1.0110146420
GSE9593Down-1.0043857965
GSE43922Down-0.1112773941
GSE24585Down-0.8891781734
GSE37065Down-0.0526976705
GSE28863_A1Down-0.6051013071
GSE28863_A2Down-1.9481200786
GSE28863_A3Down-0.7278057791
GSE28863_A4Up0.3472714958
GSE48662Up0.2994132756

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-148b-3pMIMAT0000759NAhsa-miR-148b21205300
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22072987Bmp2 was the most activated secreted factor with H3K4me3 gain and H3K27me3 loss, whereas H3K4me3 loss and de novo formation of H3K27me3 occurred inversely in repression of nine genes, including two BMP-SMAD inhibitors Smad6 and Noggin
22072987Senescence was bypassed in Ras-activated cells when Bmp2/Smad1 signal was blocked by Bmp2 knockdown, Smad6 induction, or Noggin induction
Entries Per Page
Displaying Page of