HCSGD entry for ARHGAP18
1. General information
| Official gene symbol | ARHGAP18 |
|---|---|
| Entrez ID | 93663 |
| Gene full name | Rho GTPase activating protein 18 |
| Other gene symbols | MacGAP SENEX bA307O14.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0104527716 | 0.6270088978 | 0.2610316888 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7076343744 |
| GSE13712_SHEAR | Down | -0.3199068712 |
| GSE13712_STATIC | Down | -0.2435411179 |
| GSE19018 | Up | 0.5460623932 |
| GSE19899_A1 | Up | 1.3229935743 |
| GSE19899_A2 | Up | 0.3559126151 |
| PubMed_21979375_A1 | Down | -0.4828520153 |
| PubMed_21979375_A2 | Up | 0.3425808510 |
| GSE35957 | Up | 0.6145778301 |
| GSE36640 | Up | 0.8169376981 |
| GSE54402 | Up | 0.5748578769 |
| GSE9593 | Up | 0.2066697785 |
| GSE43922 | Up | 0.4938277597 |
| GSE24585 | Down | -0.3121488319 |
| GSE37065 | Down | -0.4048715071 |
| GSE28863_A1 | Down | -0.1230879411 |
| GSE28863_A2 | Up | 0.3181624489 |
| GSE28863_A3 | Down | -0.1837943651 |
| GSE28863_A4 | Up | 0.0499489135 |
| GSE48662 | Down | -0.4192529290 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25407919 | Senescent EC induced by either the overexpression of ARHGAP18/SENEX or by H(2)O(2) showed significantly increased numbers of caveolae and associated proteins Caveolin-1, cavin-1 and cavin-2 |
| 25407919 | Depletion of these proteins by RNA interference decreased senescence induced by ARHGAP18 and by H(2)O(2) |
| 25407919 | ARHGAP18 overexpression induced a predominantly anti-inflammatory senescent population and depletion of the caveolae-associated proteins resulted in the preferential reduction in this senescent population as measured by neutrophil adhesion and adhesion protein expression after TNFalpha treatment |
| 25407919 | In confirmation, EC isolated from the aortas of CAV-1(-/-) mice failed to induce this anti-inflammatory senescent cell population upon expression of ARHGAP18, whereas EC from wild-type mice showed a significant increase |
| 25311168 | In addition, increased expression of CDKN2A and its transcriptional activators ETS1 and ARHGAP18 (SENEX) along with decreased expression of CDKN2A inhibitor ID1 were detected in FECD samples |
| 24334613 | However, we have previously shown that senescence induced by overexpression ofSENEX (or ARHGAP18), in endothelial cells results in an anti-inflammatory phenotype |
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