HCSGD entry for HAND2

1. General information

Official gene symbolHAND2
Entrez ID9464
Gene full nameheart and neural crest derivatives expressed 2
Other gene symbolsDHAND2 Hed Thing2 bHLHa26 dHand
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDAcellular_component
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001525AngiogenesisIEAbiological_process
GO:0001701In utero embryonic developmentISSbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0001967Suckling behaviorIEAbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0003219Cardiac right ventricle formationIEAbiological_process
GO:0003253Cardiac neural crest cell migration involved in outflow tract morphogenesisIEAbiological_process
GO:0003266Regulation of secondary heart field cardioblast proliferationISSbiological_process
GO:0003278Apoptotic process involved in heart morphogenesisIEAbiological_process
GO:0003357Noradrenergic neuron differentiationNASbiological_process
GO:0003680AT DNA bindingIDAmolecular_function
GO:0003713Transcription coactivator activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005667Transcription factor complexISScellular_component
GO:0006355Regulation of transcription, DNA-templatedISSbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006915Apoptotic processISSbiological_process
GO:0007507Heart developmentNASbiological_process
GO:0007512Adult heart developmentIEPbiological_process
GO:0008134Transcription factor bindingISSmolecular_function
GO:0010463Mesenchymal cell proliferationIEAbiological_process
GO:0010667Negative regulation of cardiac muscle cell apoptotic processISSbiological_process
GO:0014032Neural crest cell developmentISSbiological_process
GO:0033613Activating transcription factor bindingISSmolecular_function
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043392Negative regulation of DNA bindingIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0043586Tongue developmentIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048485Sympathetic nervous system developmentIEAbiological_process
GO:0048538Thymus developmentISSbiological_process
GO:0048935Peripheral nervous system neuron developmentIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0060982Coronary artery morphogenesisIEAbiological_process
GO:0061032Visceral serous pericardium developmentIEAbiological_process
GO:0061309Cardiac neural crest cell development involved in outflow tract morphogenesisISSbiological_process
GO:0061325Cell proliferation involved in outflow tract morphogenesisIEAbiological_process
GO:0070888E-box bindingIDA ISSmolecular_function
GO:2000679Positive regulation of transcription regulatory region DNA bindingIDAbiological_process
GO:2000763Positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic processISSbiological_process
GO:2000764Positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89471757910.44173045100.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1122442639
GSE13712_SHEARDown-0.2199795290
GSE13712_STATICUp0.0943909883
GSE19018Down-0.0059466092
GSE19899_A1Down-0.1581631091
GSE19899_A2Down-0.0152028163
PubMed_21979375_A1Down-0.1109531601
PubMed_21979375_A2Up0.0037554610
GSE35957Down-0.0596115893
GSE36640Down-0.1338251762
GSE54402Down-0.0186276284
GSE9593Down-0.0425058009
GSE43922Up0.0274089756
GSE24585Down-0.0579182952
GSE37065Down-0.1090983786
GSE28863_A1Up0.2202444851
GSE28863_A2Down-0.0468710770
GSE28863_A3Up0.1111907809
GSE28863_A4Up0.0378390045
GSE48662Down-0.0198047100

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001843qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-1MIMAT0000416MIRT001843Reporter assay;OtherFunctional MTI15951802
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.