HCSGD entry for AKAP5
1. General information
| Official gene symbol | AKAP5 |
|---|---|
| Entrez ID | 9495 |
| Gene full name | A kinase (PRKA) anchor protein 5 |
| Other gene symbols | AKAP75 AKAP79 H21 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006605 | Protein targeting | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008179 | Adenylate cyclase binding | IPI | molecular_function |
| GO:0010739 | Positive regulation of protein kinase A signaling | IMP | biological_process |
| GO:0030819 | Positive regulation of cAMP biosynthetic process | IMP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0051018 | Protein kinase A binding | TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9466614566 | 0.0795267125 | 0.9999902473 | 0.5326573791 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0475128538 |
| GSE13712_SHEAR | Down | -0.1763537935 |
| GSE13712_STATIC | Up | 0.0360174613 |
| GSE19018 | Down | -0.1501228415 |
| GSE19899_A1 | Down | -0.0118958113 |
| GSE19899_A2 | Up | 0.1002533635 |
| PubMed_21979375_A1 | Down | -0.0886773823 |
| PubMed_21979375_A2 | Down | -0.1484358097 |
| GSE35957 | Up | 0.1165215372 |
| GSE36640 | Down | -0.6095713183 |
| GSE54402 | Down | -0.1911263005 |
| GSE9593 | Down | -0.0923649734 |
| GSE43922 | Up | 0.0133152163 |
| GSE24585 | Up | 0.3157025146 |
| GSE37065 | Down | -0.0051080866 |
| GSE28863_A1 | Down | -0.0089754062 |
| GSE28863_A2 | Down | -0.8157140497 |
| GSE28863_A3 | Down | -0.8182924971 |
| GSE28863_A4 | Down | -0.1142168811 |
| GSE48662 | Up | 0.0561141992 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029184 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17081159 | We found that levels of protein kinase C (PKC)-dependent AKAPs, such as Gravin and AKAP79, were elevated in senescent cells |
| 17081159 | Co-immunoprecipitation experiments revealed that Gravin and AKAP79 do not associate with adenylyl cyclase type 2 (AC2) but bind to AC4/6, which interacts with calcium-dependent PKCs alpha/beta both in young and senescent fibroblasts |
| 17081159 | When the expression of Gravin and AKAP79 was blocked by small interference RNA transfection, the basal level of cAMP was greatly reduced and the cAMP status after LPA treatment was also reversed |
| 17081159 | These data suggest that Gravin and to a lesser extent, AKAP79, may play important roles in maintaining the basal AC activity and in coupling the AC systems to inhibitory signals such as Gialpha in young cells, and to stimulatory signals such as PKCs in senescent cells |
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