HCSGD entry for CD40LG
1. General information
| Official gene symbol | CD40LG |
|---|---|
| Entrez ID | 959 |
| Gene full name | CD40 ligand |
| Other gene symbols | CD154 CD40L HIGM1 IGM IMD3 T-BAM TNFSF5 TRAP gp39 hCD40L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005164 | Tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0005174 | CD40 receptor binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006954 | Inflammatory response | IDA | biological_process |
| GO:0007159 | Leukocyte cell-cell adhesion | NAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0030168 | Platelet activation | IDA | biological_process |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0032735 | Positive regulation of interleukin-12 production | IDA | biological_process |
| GO:0042100 | B cell proliferation | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0045190 | Isotype switching | ISS | biological_process |
| GO:0048305 | Immunoglobulin secretion | IEA | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
| GO:0051023 | Regulation of immunoglobulin secretion | IEA | biological_process |
| GO:2000353 | Positive regulation of endothelial cell apoptotic process | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4254491395 | 0.9463667376 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0946172066 |
| GSE13712_SHEAR | Up | 0.1350660468 |
| GSE13712_STATIC | Up | 0.0516065290 |
| GSE19018 | Up | 0.1106633361 |
| GSE19899_A1 | Up | 0.1030599759 |
| GSE19899_A2 | Up | 0.1076349566 |
| PubMed_21979375_A1 | Down | -0.2656414283 |
| PubMed_21979375_A2 | Up | 0.0792134264 |
| GSE35957 | Up | 0.2336294819 |
| GSE36640 | Down | -0.0028304616 |
| GSE54402 | Up | 0.0206355499 |
| GSE9593 | Up | 0.1012680165 |
| GSE43922 | Up | 0.0226441998 |
| GSE24585 | Up | 0.2841791293 |
| GSE37065 | Down | -0.0042791120 |
| GSE28863_A1 | Down | -0.0347103458 |
| GSE28863_A2 | Up | 0.1040229596 |
| GSE28863_A3 | Up | 0.0903397193 |
| GSE28863_A4 | Up | 0.0779006424 |
| GSE48662 | Down | -0.1128773951 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | MIRT005463 | ELISA//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21236257 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25733583 | Normalization of DUSP4 expression using a specific siRNA improved CD4(+) T-cell activity in ICL, as this restored TCR-induced extracellular signal-regulated kinase activation and increased the expression of the costimulatory molecules CD27 and CD40L |
| 24021055 | CMV immunoglobulin M (IgM) and IgG titers were measured using chemiluminescent assays |
| 24021055 | None of the subjects showed IgM reactivity for CMV, excluding acute viral infection |
| 23386848 | The composition of the early immune repertoire is biased with prominent expression of spontaneously arising B cell clones that produce IgM with recurrent and often autoreactive binding specificities |
| 23386848 | Amongst these naturally arising antibodies (NAbs) are IgM antibodies that specifically recognized amaged and senescent cells, often via oxidation-associated neo-determinants |
| 23386848 | Recent studies have shown that IgM NAb to apoptotic cells can enhance phagocytic clearance, as well as suppress proinflammatory responses induced via Toll-like receptors, and block pathogenic IgG-immune complex (IC)-mediated inflammatory responses |
| 23386848 | Clinical surveys have suggested that anti-apoptotic cell (AC) IgM NAbs may modulate disease activity in some patients with autoimmune disease |
| 23209284 | Ig class-switch recombination simultaneously induces somatic mutations in an IgM class-switch (Ig-Smu) region of IgG B cells |
| 15106876 | To compare the natural antibody (NAb) repertoires of the most divergent vertebrates with the capacity to produce antibodies, we isolated NAbs to the same set of antigens by affinity chromatography from two species of Carcharhine sharks and from human polyclonal IgG and IgM antibody preparations |
| 1059140 | RBC treated in the same way but incubated in IgM or Iga, Ig-depleter serum, or Medium 199 alone were not phagocytized |
| 1059140 | Scanning electron microscopy, employing labeled anti-IgG, IgM, and IgA reagents, revealed that Y-RBC had essentially no Ig on their surface, whereas old RBC had IgG on their surface |
Entries Per Page
Displaying Page of
