HCSGD entry for MORF4L2
1. General information
| Official gene symbol | MORF4L2 |
|---|---|
| Entrez ID | 9643 |
| Gene full name | mortality factor 4 like 2 |
| Other gene symbols | MORFL2 MRGX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0051155 | Positive regulation of striated muscle cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9530685156 | 0.0520175069 | 0.9999902473 | 0.4290670009 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2823574342 |
| GSE13712_SHEAR | Up | 0.0782912687 |
| GSE13712_STATIC | Down | -0.1162619960 |
| GSE19018 | Up | 0.0203496582 |
| GSE19899_A1 | Down | -0.1292758874 |
| GSE19899_A2 | Down | -0.4766299923 |
| PubMed_21979375_A1 | Down | -0.4652037626 |
| PubMed_21979375_A2 | Up | 0.0333225767 |
| GSE35957 | Up | 0.1082328146 |
| GSE36640 | Up | 0.2745557754 |
| GSE54402 | Down | -0.0203218523 |
| GSE9593 | Down | -0.2872052266 |
| GSE43922 | Down | -0.1146080297 |
| GSE24585 | Down | -0.4283078191 |
| GSE37065 | Up | 0.0034102741 |
| GSE28863_A1 | Down | -0.1657834117 |
| GSE28863_A2 | Down | -0.0602838998 |
| GSE28863_A3 | Down | -0.5542996481 |
| GSE28863_A4 | Up | 0.1252746456 |
| GSE48662 | Down | -0.3636661980 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-142-3p | MIMAT0000434 | MIRT021637 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039553 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041000 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048476 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050589 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050967 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20536842 | In contrast to MORF4, MRG15 and MRGX are positive regulators of cell division |
| 15923606 | MrgX is not essential for cell growth and development in the mouse |
| 15923606 | MRGX is one of the members of MORF4/MRG family of transcriptional regulators, which are involved in cell growth regulation and cellular senescence |
| 15923606 | We have shown that MRGX and MRG15 associate with Rb in nucleoprotein complexes and regulate B-myb promoter activity |
| 15923606 | To elucidate the functions of MRGX and to explore its potential role in modulating cell growth in vivo, we have generated MrgX-deficient mice |
| 15923606 | Characterization of the expression pattern of mouse MrgX demonstrated it was ubiquitously expressed in all tissues of adult mice and also during embryogenesis and overlapped with its homolog Mrg15 |
| 15923606 | MRGX and MRG15 proteins localize predominantly to the chromatin fraction in the nucleus, although a small amount of both proteins localized to the nuclear matrix |
| 15923606 | Whereas disruption of Mrg15 results in embryonic lethality, absence of MrgX did not impair mouse development and MrgX null mice are healthy and fertile |
| 15923606 | In contrast, MRGX, which evolved later, is expressed only in vertebrates, suggesting that the lack of phenotype of MrgX-deficient mice is secondary to a compensatory effect by the evolutionarily conserved MRG15 protein but not vice versa |
| 12391155 | Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split |
| 12391155 | This family comprises MORF on chromosome 4 (MORF4) and MORF-related genes on chromosomes X and 15 (MRGX and MRG15, respectively) and is proposed to contribute to cellular senescence |
| 12391155 | While the MORFs may have common functions, MRG15, but not MRGX or MORF4, interacted with Pf1 |
| 12391155 | Therefore, MRG15 may have functions that are distinct from those of MRGX and MORF4 |
| 12391155 | Consistent with this hypothesis, Pf1 reduced transcriptional repression by Gal4-MRG15 but it had no effect on repression by MRGX and MORF4 |
| 11280020 | It is a member of a family of seven genes and only MORF4 and the MORF-related genes MRG15 and MRGX are expressed |
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