HCSGD entry for KDM4A
1. General information
| Official gene symbol | KDM4A |
|---|---|
| Entrez ID | 9682 |
| Gene full name | lysine (K)-specific demethylase 4A |
| Other gene symbols | JHDM3A JMJD2 JMJD2A TDRD14A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0014898 | Cardiac muscle hypertrophy in response to stress | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016577 | Histone demethylation | IDA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0051864 | Histone demethylase activity (H3-K36 specific) | IDA | molecular_function |
| GO:0070544 | Histone H3-K36 demethylation | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2408500095 | 0.7526310551 | 0.9276284899 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0324686073 |
| GSE13712_SHEAR | Up | 0.0862297540 |
| GSE13712_STATIC | Up | 0.0042865741 |
| GSE19018 | Up | 0.0256664261 |
| GSE19899_A1 | Up | 0.0811478843 |
| GSE19899_A2 | Down | -0.0803775409 |
| PubMed_21979375_A1 | Down | -0.3004494992 |
| PubMed_21979375_A2 | Up | 0.0249140970 |
| GSE35957 | Up | 0.0554619852 |
| GSE36640 | Up | 0.2410274398 |
| GSE54402 | Up | 0.1320866089 |
| GSE9593 | Up | 0.2115736605 |
| GSE43922 | Down | -0.0232341981 |
| GSE24585 | Up | 0.1720367919 |
| GSE37065 | Down | -0.0957147964 |
| GSE28863_A1 | Up | 0.6218996999 |
| GSE28863_A2 | Up | 0.5640468742 |
| GSE28863_A3 | Down | -0.0766318144 |
| GSE28863_A4 | Down | -0.4111036425 |
| GSE48662 | Up | 0.4746201532 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029498 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041060 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050862 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052257 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26904954 | During senescence, the decreased levels of KDM4A lysine demethylase contribute to p53 activation, however, the mechanism by which KDM4A is downregulated is unknown |
| 26904954 | We show that miR-137 targets KDM4A mRNA during Ras-induced senescence and activates both p53 and retinoblastoma (pRb) tumor suppressor pathways |
| 26904954 | Restoring the KDM4A expression contributed to bypass of miR-137-induced senescence and inhibition of endogenous miR-137 with an miRNA sponge-compromised Ras-induced senescence |
| 26868148 | We find that Fbxo22 is highly expressed in senescent cells in a p53-dependent manner, and that SCF(Fbxo22) ubiquitylated p53 and formed a complex with a lysine demethylase, KDM4A |
| 26868148 | Ectopic expression of a catalytic mutant of KDM4A stabilizes p53 and enhances p53 interaction with PHF20 in the presence of Fbxo22 |
| 23168260 | In a search for cooperating oncogenes, we identify the lysine demethylase JMJD2A/KDM4A |
| 23168260 | We show that JMJD2A functions as a negative regulator of Ras-induced senescence and collaborates with oncogenic Ras to promote cellular transformation by negatively regulating the p53 pathway |
| 23168260 | In addition, we show that JMJD2A is overexpressed in mouse and human lung cancers |
| 23168260 | Depletion of JMJD2A in the human lung cancer cell line A549 bearing an activated K-Ras allele triggers senescence |
| 23168260 | We propose that JMJD2A is an oncogene that represents a target for Ras-expressing tumors |
Entries Per Page
Displaying Page of
