HCSGD entry for PIEZO1
1. General information
| Official gene symbol | PIEZO1 |
|---|---|
| Entrez ID | 9780 |
| Gene full name | piezo-type mechanosensitive ion channel component 1 |
| Other gene symbols | FAM38A Mib |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005261 | Cation channel activity | ISS | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | ISS | cellular_component |
| GO:0006812 | Cation transport | ISS | biological_process |
| GO:0008381 | Mechanically-gated ion channel activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0033116 | Endoplasmic reticulum-Golgi intermediate compartment membrane | IEA | cellular_component |
| GO:0033625 | Positive regulation of integrin activation | IMP | biological_process |
| GO:0033634 | Positive regulation of cell-cell adhesion mediated by integrin | IMP | biological_process |
| GO:0034220 | Ion transmembrane transport | ISS | biological_process |
| GO:0042391 | Regulation of membrane potential | IEA | biological_process |
| GO:0050982 | Detection of mechanical stimulus | IEA | biological_process |
| GO:0055085 | Transmembrane transport | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9580714069 | 0.1599383192 | 0.9999902473 | 0.7725874702 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2568539420 |
| GSE13712_SHEAR | Up | 0.1019815366 |
| GSE13712_STATIC | Up | 0.0165591677 |
| GSE19018 | Down | -0.0669491713 |
| GSE19899_A1 | Down | -0.3132934875 |
| GSE19899_A2 | Down | -0.1445929143 |
| PubMed_21979375_A1 | Up | 0.2782368348 |
| PubMed_21979375_A2 | Down | -0.1479601915 |
| GSE35957 | Down | -0.0475509771 |
| GSE36640 | Up | 0.1055890226 |
| GSE54402 | Down | -0.2401647907 |
| GSE9593 | Up | 0.1888154096 |
| GSE43922 | Down | -0.1905370573 |
| GSE24585 | Down | -0.1523869173 |
| GSE37065 | Down | -0.1616457091 |
| GSE28863_A1 | Down | -0.0393416097 |
| GSE28863_A2 | Up | 0.0356783160 |
| GSE28863_A3 | Down | -0.0689760848 |
| GSE28863_A4 | Down | -0.1758217147 |
| GSE48662 | Up | 0.0360804347 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-10b-5p | MIMAT0000254 | MIRT006294 | Luciferase reporter assay | Functional MTI | 22322955 |
| hsa-miR-940 | MIMAT0004983 | MIRT036601 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
