HCSGD entry for MAML1
1. General information
| Official gene symbol | MAML1 |
|---|---|
| Entrez ID | 9794 |
| Gene full name | mastermind-like 1 (Drosophila) |
| Other gene symbols | Mam-1 Mam1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex | IDA | cellular_component |
| GO:0003162 | Atrioventricular node development | ISS | biological_process |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007219 | Notch signaling pathway | IDA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010831 | Positive regulation of myotube differentiation | IGI | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0042605 | Peptide antigen binding | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045445 | Myoblast differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0060928 | Atrioventricular node cell development | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9372483834 | 0.1099118233 | 0.9999902473 | 0.6347058140 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3707053641 |
| GSE13712_SHEAR | Down | -0.1569741854 |
| GSE13712_STATIC | Down | -0.0741089397 |
| GSE19018 | Down | -0.5616899231 |
| GSE19899_A1 | Down | -0.4340360589 |
| GSE19899_A2 | Up | 0.0156225902 |
| PubMed_21979375_A1 | Up | 0.1340166992 |
| PubMed_21979375_A2 | Up | 0.2120010084 |
| GSE35957 | Down | -0.3452609787 |
| GSE36640 | Down | -0.3246318667 |
| GSE54402 | Up | 0.1225714732 |
| GSE9593 | Down | -0.4427729826 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.1766828378 |
| GSE28863_A2 | Up | 0.3095268793 |
| GSE28863_A3 | Up | 0.0321451029 |
| GSE28863_A4 | Down | -0.1346948138 |
| GSE48662 | Up | 0.0141430582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022154 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048105 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049055 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22864395 | A knockdown of Maml1 that results in melanoma cell senescence promotes an innate and adaptive immune response |
| 22864395 | Maml1 is emerging as a coactivator of many signaling pathways, including the Notch and Wnt pathways |
| 22864395 | This result demonstrates that the knockdown of Maml1 transcription and function contributes to increased immune surveillance |
| 22864395 | The knockdown of Maml1 transcription in the human melanoma cell line M537 also results in senescence, IFNbeta upregulation, increased chemokine gene expression, and greater NK and CD8(+) T cell migration in a transwell system |
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